Document Detail

Soluble serum interleukin 2 receptors in patients with asthma and allergic bronchopulmonary aspergillosis.
MedLine Citation:
PMID:  7788514     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When T cells are activated, they produce two distinct surface receptors for interleukin 2 (IL2). One of these surface receptors is a 55-kD protein called IL2Ra which is released into peripheral blood following T cell activation. This soluble protein (sIL2R) can be measured in peripheral blood utilizing an ELISA, and thus provides an indirect indicator of T cell activation. OBJECTIVE: The purpose of this study was to determine whether allergic bronchopulmonary aspergillosis (ABPA) was associated with increased soluble interleukin 2 receptors (sIL2R). METHODS: We used the Immunoenzymometric Assay Kit (Immunotech International, Marseille, France) which had a monoclonal antibody to sIL2R to sensitize wells. To determine the degree of T cell activation in patients with asthma and ABPA, we have evaluated the concentration of sIL2R in the peripheral blood in four groups: (1) 26 nonatopic patients, (2) 39 patients skin test positive to Aspergillus who did not have serologic evidence of ABPA, (3) 14 patients with quiescent ABPA, and (4) 13 patients who had a new roentgenographic infiltrate from ABPA. RESULTS: The mean concentration of sIL2R in the four groups were 24.5 pM (+/- 16.7), 38.4 pM (+/- 27.2), 48.4 pM (+/- 28.2), and 64.8 pM (+/- 33.0), respectively. Group 4 was greater than groups 1 and 2 (P < .05), and group 3 was greater than group 1 (P < .05). CONCLUSIONS: In patients with ABPA that is flaring, there is greater T cell activation than in either nonatopic controls or in patients who have asthma. Patients with ABPA in remission also had significantly greater T cell activation than nonatopic controls.
J E Brown; P A Greenberger; P R Yarnold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  74     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-25     Completed Date:  1995-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  484-8     Citation Subset:  IM    
Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA.
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MeSH Terms
Aspergillosis, Allergic Bronchopulmonary / blood*,  pathology
Aspergillus fumigatus / chemistry
Asthma / blood*,  pathology
Fungal Proteins / blood
Immunoglobulin E / blood
Lymphocyte Activation
Prednisone / pharmacology
Receptors, Interleukin-2 / analysis*,  chemistry
Reproducibility of Results
T-Lymphocytes / immunology
Reg. No./Substance:
0/Fungal Proteins; 0/Receptors, Interleukin-2; 37341-29-0/Immunoglobulin E; 53-03-2/Prednisone

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