| Soluble serum interleukin 2 receptors in patients with asthma and allergic bronchopulmonary aspergillosis. | |
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MedLine Citation:
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PMID: 7788514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: When T cells are activated, they produce two distinct surface receptors for interleukin 2 (IL2). One of these surface receptors is a 55-kD protein called IL2Ra which is released into peripheral blood following T cell activation. This soluble protein (sIL2R) can be measured in peripheral blood utilizing an ELISA, and thus provides an indirect indicator of T cell activation. OBJECTIVE: The purpose of this study was to determine whether allergic bronchopulmonary aspergillosis (ABPA) was associated with increased soluble interleukin 2 receptors (sIL2R). METHODS: We used the Immunoenzymometric Assay Kit (Immunotech International, Marseille, France) which had a monoclonal antibody to sIL2R to sensitize wells. To determine the degree of T cell activation in patients with asthma and ABPA, we have evaluated the concentration of sIL2R in the peripheral blood in four groups: (1) 26 nonatopic patients, (2) 39 patients skin test positive to Aspergillus who did not have serologic evidence of ABPA, (3) 14 patients with quiescent ABPA, and (4) 13 patients who had a new roentgenographic infiltrate from ABPA. RESULTS: The mean concentration of sIL2R in the four groups were 24.5 pM (+/- 16.7), 38.4 pM (+/- 27.2), 48.4 pM (+/- 28.2), and 64.8 pM (+/- 33.0), respectively. Group 4 was greater than groups 1 and 2 (P < .05), and group 3 was greater than group 1 (P < .05). CONCLUSIONS: In patients with ABPA that is flaring, there is greater T cell activation than in either nonatopic controls or in patients who have asthma. Patients with ABPA in remission also had significantly greater T cell activation than nonatopic controls. |
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Authors:
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J E Brown; P A Greenberger; P R Yarnold |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Volume: 74 ISSN: 1081-1206 ISO Abbreviation: Ann. Allergy Asthma Immunol. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-25 Completed Date: 1995-07-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9503580 Medline TA: Ann Allergy Asthma Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 484-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Northwestern University Medical School, Chicago, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillosis, Allergic Bronchopulmonary
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blood*,
pathology Aspergillus fumigatus / chemistry Asthma / blood*, pathology Female Fungal Proteins / blood Humans Immunoglobulin E / blood Lymphocyte Activation Male Prednisone / pharmacology Receptors, Interleukin-2 / analysis*, chemistry Reproducibility of Results Solubility T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Receptors, Interleukin-2; 37341-29-0/Immunoglobulin E; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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