| Soluble receptor for advanced glycation end products in physiological and pathological pregnancy. | |
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MedLine Citation:
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PMID: 19909734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The receptor for advanced glycation end products, RAGE, has been implicated in pathogenesis of many diseases. Soluble RAGE, sRAGE, extracellular domain of RAGE, is new biomarker. The aim of the study was to determine sRAGE levels in physiological pregnancy and their changes in pregnancies complicated by preterm labor or preeclampsia. DESIGN AND METHODS: Serum levels of sRAGE were determined in 79 healthy pregnant women, 42 pregnant women in preterm labor or with preeclampsia and 24 non-pregnant controls. RESULTS: sRAGE serum levels are decreased in physiological pregnancy compared to healthy non-pregnant controls (p<0.001). Serum sRAGE concentrations are higher in the 2nd trimester of physiological pregnancy, compared to the 1st and 3rd trimesters of pregnancy (p<0.001). sRAGE levels in women with preterm labor are decreased (p<0.05) and correlate negatively with the leukocyte count (r=-0.47, p<0.05). In women with preeclampsia, sRAGE is elevated (p<0.05) and correlates with serum creatinine concentration (r=0.54, p<0.05) and with uric acid concentration (r=0.51, p<0.05). CONCLUSION: Our results clearly demonstrate significant differences in serum sRAGE levels in physiological pregnancy and in pathological states in pregnancy, however, further studies are required demonstrate the usefulness and significance of sRAGE. |
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Authors:
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Anna Germanov?; Michal Kouck?; Zdenek H?jek; Anton?n Par?zek; Tom?s Zima; Marta Kalousov? |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-10 |
Journal Detail:
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Title: Clinical biochemistry Volume: 43 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-05-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 442-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Clinical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Obstetric Labor, Premature / blood* Pre-Eclampsia / blood* Pregnancy Pregnancy Trimesters / blood Receptors, Immunologic / blood* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Immunologic; 0/advanced glycosylation end-product receptor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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