Document Detail


Soluble polymer-supported organic synthesis.
MedLine Citation:
PMID:  10955985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Soluble polymers have been used as supports for reagent/catalyst immobilization and synthesis. Two polymers are commonly used in this context, linear polystyrene and poly(ethylene glycol). The complementary solubility properties of these polymers allow access to a wide range of chemistries. Parallel and combinatorial libraries of small molecules have been prepared using these polymers, and reagents/catalysts that are easily recovered and recycled have been immobilized on them. To develop soluble polymers with novel properties, bifunctional polymerization initiators have been used in a parallel combinatorial methodology to prepare block copolymers that exhibit unique solubility profiles.
Authors:
P H Toy; K D Janda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Accounts of chemical research     Volume:  33     ISSN:  0001-4842     ISO Abbreviation:  Acc. Chem. Res.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-25     Completed Date:  2000-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0157313     Medline TA:  Acc Chem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  546-54     Citation Subset:  IM    
Affiliation:
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
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MeSH Terms
Descriptor/Qualifier:
Indicators and Reagents
Organic Chemicals / chemical synthesis*
Polymers / chemistry*
Solubility
Grant Support
ID/Acronym/Agency:
GM-56154/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Organic Chemicals; 0/Polymers

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