| Soluble polymer-supported organic synthesis. | |
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MedLine Citation:
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PMID: 10955985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soluble polymers have been used as supports for reagent/catalyst immobilization and synthesis. Two polymers are commonly used in this context, linear polystyrene and poly(ethylene glycol). The complementary solubility properties of these polymers allow access to a wide range of chemistries. Parallel and combinatorial libraries of small molecules have been prepared using these polymers, and reagents/catalysts that are easily recovered and recycled have been immobilized on them. To develop soluble polymers with novel properties, bifunctional polymerization initiators have been used in a parallel combinatorial methodology to prepare block copolymers that exhibit unique solubility profiles. |
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Authors:
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P H Toy; K D Janda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Accounts of chemical research Volume: 33 ISSN: 0001-4842 ISO Abbreviation: Acc. Chem. Res. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2000-09-25 Completed Date: 2000-09-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0157313 Medline TA: Acc Chem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 546-54 Citation Subset: IM |
Affiliation:
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Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Indicators and Reagents Organic Chemicals / chemical synthesis* Polymers / chemistry* Solubility |
| Grant Support | |
ID/Acronym/Agency:
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GM-56154/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Organic Chemicals; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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