Document Detail

Soluble interleukin-6 receptor levels in pleural effusions.
MedLine Citation:
PMID:  8759474     Owner:  NLM     Status:  MEDLINE    
Generation of soluble cytokine receptors is a general phenomenon, and the roles of several such receptors have been investigated in clinical settings. Unlike other soluble cytokine receptors, soluble interleukin-6 receptor (sIL-6R) can act as an agonist and thus is implicated as an important modulator in the acute-phase reaction of prolonged inflammation. The purpose of the present study was to determine the roles of pleural sIL-6R in both differential diagnosis of pleural diseases and in the induction of acute-phase protein. Specific sandwich enzyme-linked immunosorbent assays were used to determine sIL-6R and IL-6 in 19 tuberculous, 48 malignant and 10 transudative effusions. Although IL-6 levels in pleural effusions were strikingly different, no significant differences in pleural sIL-6R levels were found between the groups. Pleural levels of IL-6 were invariably much higher, whereas those of SIL-6R were invariably lower than serum levels. Furthermore, IL-6, but not sIL-6R, levels in effusions correlated significantly with serum C-reactive protein levels. These results suggest that: (1) pleural levels of sIL-6R are not increased even in strong inflammation such as tuberculous pleurisy, nor significantly different among pleural diseases; and (2) the local levels of sIL-6R are not as important as expected for the induction of acute-phase proteins in patients with pleural diseases.
A Yokoyama; N Kohno; S Fujino; M Abe; O Ishida; K Hiwada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiratory medicine     Volume:  90     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-09-27     Completed Date:  1996-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  IM    
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
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MeSH Terms
Antigens, CD / analysis*
C-Reactive Protein / metabolism
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Interleukin-6 / analysis
Pleural Effusion / diagnosis,  immunology*,  metabolism
Pleural Effusion, Malignant / immunology,  metabolism
Receptors, Interleukin / analysis*
Receptors, Interleukin-6
Tuberculosis, Pleural / immunology*,  metabolism
Reg. No./Substance:
0/Antigens, CD; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Interleukin-6; 9007-41-4/C-Reactive Protein

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