| Soluble interleukin-6 receptor levels in pleural effusions. | |
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MedLine Citation:
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PMID: 8759474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Generation of soluble cytokine receptors is a general phenomenon, and the roles of several such receptors have been investigated in clinical settings. Unlike other soluble cytokine receptors, soluble interleukin-6 receptor (sIL-6R) can act as an agonist and thus is implicated as an important modulator in the acute-phase reaction of prolonged inflammation. The purpose of the present study was to determine the roles of pleural sIL-6R in both differential diagnosis of pleural diseases and in the induction of acute-phase protein. Specific sandwich enzyme-linked immunosorbent assays were used to determine sIL-6R and IL-6 in 19 tuberculous, 48 malignant and 10 transudative effusions. Although IL-6 levels in pleural effusions were strikingly different, no significant differences in pleural sIL-6R levels were found between the groups. Pleural levels of IL-6 were invariably much higher, whereas those of SIL-6R were invariably lower than serum levels. Furthermore, IL-6, but not sIL-6R, levels in effusions correlated significantly with serum C-reactive protein levels. These results suggest that: (1) pleural levels of sIL-6R are not increased even in strong inflammation such as tuberculous pleurisy, nor significantly different among pleural diseases; and (2) the local levels of sIL-6R are not as important as expected for the induction of acute-phase proteins in patients with pleural diseases. |
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Authors:
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A Yokoyama; N Kohno; S Fujino; M Abe; O Ishida; K Hiwada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Respiratory medicine Volume: 90 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-27 Completed Date: 1996-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 329-32 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Ehime University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis* C-Reactive Protein / metabolism Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Humans Interleukin-6 / analysis Pleural Effusion / diagnosis, immunology*, metabolism Pleural Effusion, Malignant / immunology, metabolism Receptors, Interleukin / analysis* Receptors, Interleukin-6 Tuberculosis, Pleural / immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Interleukin-6; 0/Receptors, Interleukin; 0/Receptors, Interleukin-6; 9007-41-4/C-Reactive Protein |
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