Document Detail


Soluble interleukin-2 receptors in plasma cell dyscrasias.
MedLine Citation:
PMID:  2618549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of the soluble form of the interleukin-2 receptor (sIL-2R) were evaluated in the peripheral blood of 69 patients with plasma cell dyscrasias. A close relationship was seen between serum sIL-2R levels and clinical features. Among patients with normal BUN and creatinine levels, the mean (+/- 1SD) level of sIL-2R in 44 patients with multiple myeloma (MM) was higher than that of normal controls (457 +/- 227 U/ml vs 288 +/- 124 U/ml, P = 0.01). The mean level of sIL-2R in eight patients with primary macroglobulinemia was 722 +/- 251 U/ml. In MM, those with active or refractory disease showed a significantly higher mean level of sIL-2R than those in the remission phase (577 +/- 240 U/ml vs 335 +/- 103 U/ml, P = 0.01). There was a negative correlation between sIL-2R and hemoglobin levels in MM patients (r = -0.45, P = 0.01). Five patients with complications of renal insufficiency had elevated levels of sIL-2R. In a longitudinal study of a patient with plasmacytoma and an extremely high sIL2-R level, the sIL-2R level showed a strong relationship with tumor burden. Patients with high sIL-2R levels generally had a poor prognosis than those with normal levels. Thus a high sIL-2R level may be an indicator of a poor prognosis in MM.
Authors:
T Takamatsu; N Yasuda; T Ohno; T Kanoh; H Uchino; H Fujii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society     Volume:  52     ISSN:  0001-5806     ISO Abbreviation:  Nippon Ketsueki Gakkai Zasshi     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1990-03-06     Completed Date:  1990-03-06     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  2984803R     Medline TA:  Nihon Ketsueki Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  749-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Humans
Male
Middle Aged
Paraproteinemias / blood*
Receptors, Interleukin-2 / blood*
Solubility
Chemical
Reg. No./Substance:
0/Receptors, Interleukin-2

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