| Soluble interleukin 2 receptor levels in children with type I insulin-dependent diabetes mellitus. | |
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MedLine Citation:
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PMID: 7762968 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soluble interleukin 2 receptor (sIL-2R) levels reflect mononuclear cell activation and are elevated in a variety of autoimmune, neoplastic and infectious conditions. Several investigators have studied sIL-2R levels in patients with Type I diabetes mellitus (IDDM), but results have been conflicting. Our primary objective in this study was to compare sIL-2R levels of children and adolescents with newly diagnosed IDDM with those of age-matched controls. In addition, sIL-2R levels in a cohort of patients were followed longitudinally for 1 to 2 years after diagnosis. Serum sIL-2R levels of 38 IDDM children and adolescents (age < 20 years) were compared with levels of 39 nondiabetic, age-matched controls. Mean sIL-2R levels declined with age (P < 0.000005), and there was no significant difference in the regression line relating age and sIL-2R levels between patients and controls. The sIL-2R levels remained fairly consistent over 1-2 years of follow up. The presence of islet cell antibodies (ICA) had no apparent effect on sIL-2R levels in children with diabetes. The sIL-2R levels were similar in magnitude among first degree relatives of patients with IDDM compared to the range of unrelated subjects. It is our conclusion that sIL-2R levels are highest during infancy and decline throughout childhood. The sIL-2R levels do not appear to be clinically useful as a reflection of immune activation in patients with IDDM. Finally, there may be a genetic influence which partially regulates production of sIL-2R. |
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Authors:
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L A Gartner; M C Pfeifer; C Albini; G L Francis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Annals of clinical and laboratory science Volume: 25 ISSN: 0091-7370 ISO Abbreviation: Ann. Clin. Lab. Sci. Publication Date: 1995 Jan-Feb |
Date Detail:
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Created Date: 1995-06-29 Completed Date: 1995-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410247 Medline TA: Ann Clin Lab Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 44-51 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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blood Case-Control Studies Child Cohort Studies Diabetes Mellitus, Type 1 / blood* Female Humans Islets of Langerhans / immunology Male Matched-Pair Analysis Receptors, Interleukin-2 / analysis* Solubility |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Receptors, Interleukin-2; 0/islet cell antibody |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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