Document Detail


Soluble interleukin 2 receptor levels in families of people with schizophrenia.
MedLine Citation:
PMID:  12072172     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Several authors have reported increased soluble interleukin 2 receptor (sIL2Ralpha) concentrations in schizophrenia. The aim of this work was to examine serum sIL2Ralpha in the first degree relatives of patients with schizophrenia. METHODS: We sampled 51 first degree relatives of patients with DSM IIIR schizophrenia. These relatives were unaffected by psychosis and included nine fathers, thirteen mothers, seventeen sisters and twelve brothers. They were compared to 126 controls who were not pregnant, had no known autoimmune disorder and no intercurrent illness. Neither the controls, nor their first degree relatives, suffered from a psychotic illness. Serum sIL2Ralpha was analysed using a commercial ELISA preparation (Quantikine sIL2Ralpha immunoassay - R and D Systems, Inc.). We used non-parametric Mann Whitney U test and Spearman correlation throughout. SIL2Ralpha levels were adjusted for higher levels in females and with increasing age. RESULTS: Adjusted mean sIL2Ralpha values of unaffected siblings, averaged within their families, were higher than controls (n=14, one-tailed p=0.027). There was no difference in sIL2Ralpha values between fathers or mothers and controls following regression for age and sex. CONCLUSION: Soluble interleukin 2 receptoralpha levels are increased in siblings of patients with schizophrenia.
Authors:
Fiona Gaughran; Evonne O'Neill; Pak Sham; Robert J Daly; Fergus Shanahan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  56     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-06-19     Completed Date:  2002-07-30     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Affiliation:
South London and Maudsley Trust, London, UK. fiona.gaughran@slam-tr.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Humans
Male
Middle Aged
Nuclear Family*
Receptors, Interleukin-2 / blood*
Schizophrenia / immunology*
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Receptors, Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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