| Soluble interleukin 2 receptor and interleukin 1alpha in toxic epidermal necrolysis: a comparative analysis of serum and blister fluid samples. | |
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MedLine Citation:
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PMID: 11790164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare but severe adverse drug disease, characterized by extensive skin and mucosal detachment with participation of different immunoinflammatory pathways, in particular with early participation of activated CD8+ T lymphocytes. OBJECTIVE: To further study the potential role of T lymphocytes in the early phase of keratinocyte necrosis. DESIGN: Prospective study. SETTING: University hospitals. PATIENTS: Thirteen patients with clinical and histopathologic criteria of TEN and 6 patients with second-degree burns. MAIN OUTCOME MEASURES: Measurement of soluble interleukin (IL) 2 receptor (sIL-2R) and IL-1alpha in serum samples and fluid of recent blisters. RESULTS: In the blister fluid of patients with TEN, we found significantly higher levels of sIL-2R than in patients with burns, whereas IL-1alpha levels were higher in the blister fluid of burned patients. No significant differences were found in serum samples of patients with TEN and burns, in either sIL-2R or IL-1alpha. In TEN we also found significantly higher levels of sIL-2R in the blister fluid compared with serum samples, pointing to a predominantly local production contrasting with the low concentration of sIL-2R in the blister fluid of burned patients. CONCLUSIONS: Our findings of elevated sIL-2R levels in blister fluid of patients with TEN are probably related to a local down-regulation of an immunologically mediated cytotoxic reaction and further support the involvement of activated T lymphocytes in the early blisters of TEN. |
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Authors:
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Osvaldo Correia; Luis Delgado; Jean-Claude Roujeau; Laurence Le Cleach; José A Fleming-Torrinha |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of dermatology Volume: 138 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-02-05 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 29-32 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Instituto Português Oncologia, 4200 Porto, Portugal. osvaldo.correia@netc.pt |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biological Markers / blood Blister Burns / blood, diagnosis* Epidermal Necrolysis, Toxic / blood, diagnosis* Female Humans Interleukin-1 / blood* Male Middle Aged Probability Prospective Studies Receptors, Interleukin-2 / blood* Reference Values Sensitivity and Specificity Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-1; 0/Receptors, Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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