| Soluble intercellular adhesion molecule 1 in umbilical cord serum: potential for the diagnosis of neonatal infections. | |
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MedLine Citation:
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PMID: 11914570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the diagnostic relevance to neonatal infections of the soluble intercellular adhesion molecule 1 (sICAM-1) cord serum level. METHODS: The case-control study included 66 term newborn infants with and without risk factors for neonatal infections. Cord blood serum determinations of white blood cell count, C-reactive protein, fibrinogen, and sICAM-1 were systematically performed associated with bacterial cultures from placenta, ears, and gastric fluids. RESULTS: 6 of 33 infants (18.2%) with risk factors were infected, and 13 (39.4%) were colonized. Two infants included in the group without infection risk factors (n = 33) were colonized. No difference in sICAM-1 cord serum levels was found according to the presence of premature rupture of membrane, fetal tachycardia >160 bpm, meconial amniotic fluid, and duration of labour >10 h. No difference in sICAM-1 was noted between infected and non-infected infants. The cord serum levels of sICAM-1 were significantly higher in infants after forceps extraction (p = 0.01). A correlation was observed between sICAM-1 and C-reactive protein cord serum levels (p = 0.004, r = 0.371) and between sICAM-1 level and neutrophil count (p = 0.01, r = 0.489). CONCLUSIONS: Our results suggest that cord serum sICAM-1 determinations have no diagnostic relevance to neonatal infection. The increase of sICAM-1 cord serum levels in infants after forceps extraction suggests its potential to evaluate cerebral trauma or hypoxia. |
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Authors:
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Emile Daraï; Christophe Poncelet; David Soriano; Veronique Lejeune; Annie-France Bringuier; Patrick Madelenat; Gerard Feldmann; Jean-Yves Scoazec |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 17 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2002 May-Jun |
Date Detail:
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Created Date: 2002-03-26 Completed Date: 2002-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 167-72 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Service de Gynécologie-Obstétrique, Hôpital Bichat-Claude-Bernard, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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isolation & purification Bacterial Infections / diagnosis* C-Reactive Protein / analysis Case-Control Studies Delivery, Obstetric / methods Ear / microbiology Fetal Blood / chemistry* Fibrinogen / analysis Gastric Juice / microbiology Humans Infant, Newborn Intercellular Adhesion Molecule-1 / blood* Leukocyte Count Obstetrical Forceps Placenta / microbiology Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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126547-89-5/Intercellular Adhesion Molecule-1; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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