Document Detail


Soluble immune complexes in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases.
MedLine Citation:
PMID:  6998248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence of soluble immune complexes (IC) in the cerebrospinal fluid (CSF) of 14 multiple sclerosis (MS) patients, four acute polyradiculoneuritis patients, 30 patients with other neurological diseases (OND) and 30 patients with disc prolapse (DP) was examined by a solid phase C1q-protein A binding assay (C1q-PABA) and a complement consumption test. IC-positive reactions were observed only in the C1q-PABA. The binding indices determined by the C1q-PABA differed significantly (P < 0.01) when the MS or the OND patient groups were compared to the DP group. No significant (P < 0.1) difference was observed between the indices in the MS and OND groups. Binding indices in C1q-PABA showed no correlation either to IgG concentration, total protein concentration or cell counts in CSF of MS patients. Three of the four polyradiculoneuritis patients were strongly IC-positive while the fourth patient was negative. Filtration and PEG-precipitation data indicated that a major part of the IgG-containing IC in CSF detected by C1q-PABA was of macromolecular nature.
Authors:
G Glikmann; S E Svehag; E Hansen; O Hansen; S Husby; H Nielsen; C Farrell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  61     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1980 Jun 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  333-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Albumins / cerebrospinal fluid
Antigen-Antibody Complex*
Complement C1
Female
Glucose / cerebrospinal fluid
Humans
Immunoglobulin G / cerebrospinal fluid
Immunologic Techniques
Intervertebral Disk Displacement / cerebrospinal fluid,  immunology
Male
Middle Aged
Multiple Sclerosis / cerebrospinal fluid,  immunology*
Nervous System Diseases / cerebrospinal fluid,  immunology*
Polyradiculoneuropathy / cerebrospinal fluid,  immunology*
Protein Binding
Staphylococcal Protein A
Chemical
Reg. No./Substance:
0/Albumins; 0/Antigen-Antibody Complex; 0/Complement C1; 0/Immunoglobulin G; 0/Staphylococcal Protein A; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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