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Soluble guanylate cyclase modulators in heart failure.
MedLine Citation:
PMID:  21207207     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This review summarizes the role of soluble guanylate cyclase (sGC)-cyclic guanosine 3', 5'-monophosphate pathways in heart failure and several new drugs that modify guanylate cyclase. The sGC activators and stimulators as modulators of sGC are promising drugs in the therapy for decompensated heart failure and pulmonary hypertension. Cinaciguat is a nitric oxide (NO)-independent direct activator of sGC, which also may be effective under oxidative stress conditions resulting in oxidized or heme-free sGC refractory to organic nitrates. Riociguat is an NO-independent direct stimulator of sGC with beneficial effects in patients with decompensated heart failure and pulmonary hypertension. The sGC modulators play an important role in patients with heart failure and pulmonary hypertension.
Authors:
Veselin Mitrovic; Ana Jovanovic; Stefan Lehinant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current heart failure reports     Volume:  8     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Affiliation:
Kerckhoff-Klinik gGmbH, Benekestrasse 2-8, Bad Nauheim, 61231, Germany, v.mitrovic@kerckhoff-klinik.de.
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