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Soluble form of ICAM-1, VCAM-1, E- and L-selectin in human milk.
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MedLine Citation:
PMID:  11132769     Owner:  NLM     Status:  MEDLINE    
In breast milk and paired serum from 70 lactating women and 40 of their term, infection-free neonates, on the 2nd and 5th day postpartum slCAM-1, sVCAM-1, sE- and sL-selectin were measured by ELISA and compared with those in 26 healthy adults (controls). Seven infant formulas and fresh milk from five cows were also analyzed. Human colostrum values of slCAM-1, sVCAM-1 (similar to those in maternal and control serum), sE-selectin and sL-selectin (-10 and -100 times lower than in maternal and control serum) were significantly higher than those in milk, while they varied widely. None of the adhesion molecules was detected in fresh cow's milk or infant formulas. Exclusively breast-fed infants showed significantly higher values of slCAM-1 and sL-selectin on the 2nd day of life than those supplemented also with formula. Only slCAM-1 values correlated positively between colostrum and time-matched maternal serum. These findings show in human milk important amounts of slCAM-1 and sVCAM-1 but minimal amounts of sE- and sL-selectin, which could affect the immune system of the neonate.
K Xyni; D Rizos; G Giannaki; A Sarandakou; I Phocas; G Creatsas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  9     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-29     Completed Date:  2001-04-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-40     Citation Subset:  IM    
Neonatal Unit, Athens University, Aretaieion University Hospital, Greece.
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MeSH Terms
Breast Feeding
Case-Control Studies
E-Selectin / blood,  metabolism*
Infant Food / analysis
Infant, Newborn
Intercellular Adhesion Molecule-1 / blood,  metabolism*
L-Selectin / blood,  metabolism*
Lactation / blood,  metabolism
Milk / chemistry
Milk, Human / immunology*,  metabolism*
Vascular Cell Adhesion Molecule-1 / blood,  metabolism*
Reg. No./Substance:
0/E-Selectin; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 126880-86-2/L-Selectin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
Article Information
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Print publication date: Year: 2000
Volume: 9 Issue: 3-4
First Page: 133 Last Page: 140
ID: 1781762
PubMed Id: 11132769

Soluble form of ICAM-1, VCAM-1, E- and L-selectin in human milk.
K Xyni
D Rizos
G Giannaki
A Sarandakou
I Phocas
G Creatsas
Neonatal Unit, Athens University, Aretaieion University Hospital, Greece.

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  • Research Article

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