Document Detail

Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood.
MedLine Citation:
PMID:  8586774     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Psyllium, a water-soluble fiber, has been shown to have a cholesterol-lowering effect in studies of adults. A small number of studies in children have produced variable results. METHODS: A 12-week, randomized, single-blind, placebo-controlled, parallel clinical trial was conducted to test the effectiveness of psyllium in lowering total (TC) and low-density lipoprotein cholesterol (LDL-C) in 50 healthy 2 to 11 year old children. Children with two baseline LDL-C levels > or = 110 mg/dL were invited to participate in the trial, and were randomly assigned to follow a usual Step I (Control) diet of low dietary fat, saturated fat and cholesterol, or a Step I diet enriched with psyllium. Children consumed two 1-oz boxes of cereal per day, with each box of psyllium-enriched cereal containing 3.2 g of soluble fiber, and each box of placebo cereal containing less than 0.5 g of soluble fiber. RESULTS: Greater reduction of total and LDL-cholesterol, and increase in HDL-cholesterol were noted after 12 weeks of the psyllium-enriched Step I diet compared to the Step I control diet. Total cholesterol decreased 21 mg/dL for the high fiber group compared with 11.5 mg/dL for the control group. LDL-C decreased 23 mg/dL for the high fiber group compared with 8.5 mg/dL for the control group. HDL-C increased 4 mg/dL for the high fiber group compared with 1 mg/dL for the controls. TC/HDL and LDL/HDL ratios decreased significantly more so for the high fiber group as well. CONCLUSIONS: In this 12-week study, soluble fiber (psyllium) provided added benefit to the Step I diet in the treatment of hypercholesterolemia.
C L Williams; M Bollella; A Spark; D Puder
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  14     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-03-28     Completed Date:  1996-03-28     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-7     Citation Subset:  IM    
American Health Foundation, New York Medical College, Valhalla, USA.
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MeSH Terms
Anticholesteremic Agents / pharmacology*
Child, Preschool
Cholesterol / blood*
Cholesterol, Dietary / administration & dosage,  pharmacology
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Diet Records
Dietary Fats / administration & dosage,  pharmacology
Dietary Fiber / administration & dosage,  standards*
Hypercholesterolemia / blood,  diet therapy*
Psyllium / pharmacology*,  therapeutic use
Regression Analysis
Single-Blind Method
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 57-88-5/Cholesterol; 8063-16-9/Psyllium

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