| Soluble epoxide hydrolase: a promising therapeutic target for cardiovascular diseases. | |
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MedLine Citation:
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PMID: 21553642 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP450) products of arachidonic acid and EETs are endogenous lipid mediators synthesized by the vascular endothelium which perform important biological functions, including vasodilation, anti-inflammation, antimigratory, and cellular signaling regulations. However, EETs are rapidly degraded by soluble epoxide hydrolase (sEH) to the corresponding diols: dihydroxyeicosatrienoic acids (DHETs), which have little active in causing vasorelaxation. A number of studies have supported that the inhibition of sEH (sEHIs) had cardiovascular protective effects in hypertension, cardiac hypertrophy, atherosclerosis, ischemia-reperfusion injury, and ischemic stroke. Moreover, sEHIs could slow the progression of inflammation, protect end-organ damage and prevent ischemic events, also, attenuate endothelial dysfunction, suggesting that the pharmacological blockade of sEH might provide a broad and novel avenue for the treatment of many cardiovascular diseases. |
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Authors:
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Guo-Hua Ni; Jin-Fang Chen; Xiao-Ping Chen; Tian-Lun Yang |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 66 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-05-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Xiang-Ya Hospital of Central South University, Changsha, PR China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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