Document Detail


Soluble adhesion molecules, endothelial markers and atherosclerosis risk factors in abdominal aortic aneurysm: a comparison with claudicants and healthy controls.
MedLine Citation:
PMID:  9818997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Development of an abdominal aortic aneurysm (AAA) may be a product of generalised atherosclerosis. If that is indeed the case, we would expect similarities in various risk factors and other markers in common with occlusive peripheral arterial disease (peripheral arterial disease), and less congruity with healthy controls. To test this hypothesis, we recorded the major risk factors for atherosclerosis, two markers of endothelial dysfunction, and soluble adhesion molecules in 21 patients with an uncomplicated AAA free of symptomatic peripheral arterial disease, 42 patients with peripheral arterial disease, and 42 healthy controls who were matched, as a group, for age and sex. After adjusting for smoking, there were no significant differences in blood pressure, fibrinogen, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1 or lipoproteins between the groups. However, markers of endothelial integrity von Willebrand factor and soluble thrombomodulin were both higher (P < 0.05) only in peripheral arterial disease patients. Relative to the controls, platelet marker soluble P-selectin was increased in AAA (P < 0.01) and in the peripheral arterial disease patients (P < 0.05). Levels were higher in AAA patients than in peripheral arterial disease patients (P < 0.05). Our laboratory data suggest that the pathophysiology AAA and peripheral arterial disease are not identical.
Authors:
A D Blann; C Devine; J Amiral; C N McCollum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  9     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
University Department of Medicine, The City Hospital, Birmingham, UK. BLANNA@novell5.bham.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aortic Aneurysm, Abdominal / blood*,  complications
Arteriosclerosis / blood*,  complications
Biological Markers / blood*
Blood Pressure
Cell Adhesion Molecules / blood*
Endothelium, Vascular*
Female
Fibrinogen / analysis
Humans
Intercellular Adhesion Molecule-1 / blood
Lipoproteins / blood
Male
Middle Aged
P-Selectin / blood
Risk Factors
Solubility
Thrombomodulin / blood
Vascular Cell Adhesion Molecule-1 / blood
von Willebrand Factor / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cell Adhesion Molecules; 0/Lipoproteins; 0/P-Selectin; 0/Thrombomodulin; 0/Vascular Cell Adhesion Molecule-1; 0/von Willebrand Factor; 126547-89-5/Intercellular Adhesion Molecule-1; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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