| Soluble TNFα receptor Type I and Hepcidin as determinants of development of anemia in the long-term follow-up of heart failure patients. | |
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MedLine Citation:
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PMID: 22609894 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Anemia is common in patients with chronic heart failure (CHF) and is associated with a worse prognosis. This study aims to identify the biological mechanisms which reflect evolutionary changes in the hemoglobin concentrations in heart failure patients who are still not anaemic. METHODS: Fifty-nine patients (54±14years, 83% males) with CHF (LVEF 28±10%), who did not have anemia, and had not received any previous transfusions, were included. The parameters studied were: iron metabolism (ferritin, iron, transferrin, soluble transferrin receptor (sTfR), hepcidin); inflammation (C-reactive protein, soluble TNFα receptor I (sTNFRI), interleukin 6); and myocardial stress (NT-proBNP, high sensitivity TnT, growth differentiation factor 15). All parameters were measured on inclusion and one year after inclusion. RESULTS: Baseline hemoglobin (g/dl) was 14.7±1.5 and at one year of follow-up it showed a significant decrease of -0.4 (RIC: -0.7 to -0.06) (p=0.02). At baseline, only the sTNFRI was a predictor of a decrease in hemoglobin one year later (p=0.007). During follow-up, the increase in sTNFRI (p=0.002, r=-0.39) and hepcidin (p=0.006, r=-0.35) were both associated with a decrease in hemoglobin. Similarly, the patients who became anemic (13%) had higher levels of hepcidin (p=0.001) and sTNFRI (p=0.008). The remaining parameters did not show any relationship with the evolution in the hemoglobin. CONCLUSIONS: In CHF patients without anemia, the increase in the inflammatory state (sTNFRI) and the following deterioration in the iron metabolism (hepcidin), were the main determinants of a decrease in hemoglobin and the appearance of anemia in the long term follow-up period. |
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Authors:
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A Martínez-Ruiz; P L Tornel-Osorio; J Sánchez-Más; J Pérez-Fornieles; J A Vílchez; P Martínez-Hernández; D A Pascual-Figal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-17 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Clinical Analysis Department, Virgen de la Arrixaca University Hospital, Murcia (Spain). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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