Document Detail

Soluble ST2 predicts elevated SBP in the community.
MedLine Citation:
PMID:  23615326     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with existing cardiovascular disease. ST2 and its ligand, interleukin-33 (IL-33), are expressed in endothelial cells, and may play an important role in the development of early atherosclerosis and vascular biology. We sought to investigate the association of sST2 and progression of blood pressure (BP), as well as the development of hypertension.
METHODS: Circulating sST2 concentrations were measured in 1834 participants (mean age 56 years, 57% women) of the community-based Framingham Offspring study. Participants were free of hypertension at baseline. Multivariable linear and logistic regression models were used to evaluate the association of sST2 concentrations and subsequent BP outcomes.
RESULTS: Higher sST2 concentrations were associated with incident hypertension over 3 years of follow-up [multivariable-adjusted odds ratio per 1 standard deviation increase in sST2 1.22, 95% confidence interval 1.05-1.42, P=0.01]. Individuals in the upper sST2 quartile had a 2.6 mmHg greater increase in SBP compared with those in the lowest quartile (P for trend across quartiles 0.002) and a 1.8 mmHg greater increase in pulse pressure (P for trend 0.005). In contrast, sST2 concentrations were not associated with changes in DBP (P=0.27).
CONCLUSION: These findings suggest that sST2 concentrations predict changes in BP physiology typically seen with aging and progressive arterial stiffness. Further studies are needed to elucidate underlying mechanisms by which the ST2/IL-33 pathway may contribute to BP physiology.
Jennifer E Ho; Martin G Larson; Anahita Ghorbani; Susan Cheng; Ramachandran S Vasan; Thomas J Wang; James L Januzzi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  31     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-09-05     Completed Date:  2014-02-10     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1431-6; discussion 1436     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood*
Hypertension / blood*
Middle Aged
Receptors, Cell Surface / blood*
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/IL1RL1 protein, human; 0/Receptors, Cell Surface

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