| Soluble HLA-I in rheumatic diseases. | |
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MedLine Citation:
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PMID: 9757946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study serum levels of Class I soluble HLA (sHLA-I) in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis or dermatomyositis (PM/DM) or scleroderma and to assess the possible influence of ethnic factors on concentration in each disease group. METHODS: Solid-phase enzyme linked immunoassay was used to measure sHLA-I in the serum of 385 patients with varied ethnic backgrounds (American-Caucasians, African-Americans, Georgian-Caucasians) with rheumatic diseases. Studies on patients were compared to similar measurements of 189 healthy individuals. RESULTS: Mean sHLA-I levels were significantly higher in patients with SLE than those observed in healthy individuals or other rheumatic diseases. Highest concentrations were present in Georgian-Caucasian patients with SLE. American-Caucasian patients with RA or scleroderma had higher sHLA-I levels than normal Caucasian individuals. The majority of patients with PM/DM in all ethnic subgroups were low secretors of sHLA-I. CONCLUSION: Mechanisms underlying the secretion of sHLA-I appear to differ among the rheumatic diseases studied and various ethnic groups. These genetic differences in sHLA-I secretion could be associated with ethnic and pathophysiologic differences among these rheumatic diseases. |
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Authors:
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R E Wolf; I M Adamashvili; F B Gelder; V C Hall; P A Fraser; J C McDonald |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Human immunology Volume: 59 ISSN: 0198-8859 ISO Abbreviation: Hum. Immunol. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-12-09 Completed Date: 1998-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8010936 Medline TA: Hum Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 644-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group Arthritis, Rheumatoid / blood, ethnology, immunology European Continental Ancestry Group Georgia (Republic) HLA Antigens / blood* Histocompatibility Antigens Class I / blood* Humans Louisiana Lupus Erythematosus, Systemic / blood, ethnology, immunology Myositis / blood, ethnology, immunology Rheumatic Diseases / blood, ethnology*, immunology* Scleroderma, Systemic / blood, ethnology, immunology Solubility West Indies / ethnology |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/Histocompatibility Antigens Class I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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