Document Detail


Soluble HLA-I in rheumatic diseases.
MedLine Citation:
PMID:  9757946     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study serum levels of Class I soluble HLA (sHLA-I) in patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis or dermatomyositis (PM/DM) or scleroderma and to assess the possible influence of ethnic factors on concentration in each disease group. METHODS: Solid-phase enzyme linked immunoassay was used to measure sHLA-I in the serum of 385 patients with varied ethnic backgrounds (American-Caucasians, African-Americans, Georgian-Caucasians) with rheumatic diseases. Studies on patients were compared to similar measurements of 189 healthy individuals. RESULTS: Mean sHLA-I levels were significantly higher in patients with SLE than those observed in healthy individuals or other rheumatic diseases. Highest concentrations were present in Georgian-Caucasian patients with SLE. American-Caucasian patients with RA or scleroderma had higher sHLA-I levels than normal Caucasian individuals. The majority of patients with PM/DM in all ethnic subgroups were low secretors of sHLA-I. CONCLUSION: Mechanisms underlying the secretion of sHLA-I appear to differ among the rheumatic diseases studied and various ethnic groups. These genetic differences in sHLA-I secretion could be associated with ethnic and pathophysiologic differences among these rheumatic diseases.
Authors:
R E Wolf; I M Adamashvili; F B Gelder; V C Hall; P A Fraser; J C McDonald
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Human immunology     Volume:  59     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-09     Completed Date:  1998-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  644-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Louisiana State University Medical Center, Shreveport 71130-3932, USA.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Arthritis, Rheumatoid / blood,  ethnology,  immunology
European Continental Ancestry Group
Georgia (Republic)
HLA Antigens / blood*
Histocompatibility Antigens Class I / blood*
Humans
Louisiana
Lupus Erythematosus, Systemic / blood,  ethnology,  immunology
Myositis / blood,  ethnology,  immunology
Rheumatic Diseases / blood,  ethnology*,  immunology*
Scleroderma, Systemic / blood,  ethnology,  immunology
Solubility
West Indies / ethnology
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/Histocompatibility Antigens Class I

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