Document Detail

Soluble HLA class I and class II molecule levels in serum and cerebrospinal fluid of multiple sclerosis patients.
MedLine Citation:
PMID:  9154458     Owner:  NLM     Status:  MEDLINE    
Increased concentrations of soluble HLA class I and class II molecules (sHLA-I and sHLA-II) have been observed in infectious, inflammatory, and autoimmune diseases. Because autoimmune mechanisms are considered to play a role in the pathogenesis of multiple sclerosis (MS), we decided to dose sHLA-I and sHLA-II in serum and cerebrospinal fluid (CSF) of MS patients comparing their concentrations with those observed in serum and CSF of patients with other neurologic diseases (OND) without evidence of neuroradiologic involvement of central nervous system (CNS) and in serum of healthy donors. The serum concentrations of sHLA-I were higher in both MS and OND patients than in healthy donors (P < 0.05) whereas sHLA-II serum concentrations were lower in MS patients than in both OND patients and healthy donors (P < 0.01). Detectable amounts of sHLA-II were observed in the CSF of 45% of MS patients and in CSF of only 6% of OND patients (P < 0.001). In MS patients a significant correlation between sHLA-I serum and CSF concentrations was observed (P < 0.01), whereas sHLA-II serum and CSF levels did not correlate. In conclusion, alterations of sHLA-I and sHLA-II serum and CSF concentrations are present in MS patients and could be involved in the induction of enhanced susceptibility to develop MS or in MS pathogenesis.
G Filaci; P Contini; S Brenci; P Gazzola; L Lanza; M Scudeletti; F Indiveri; G L Mancardi; F Puppo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human immunology     Volume:  54     ISSN:  0198-8859     ISO Abbreviation:  Hum. Immunol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-21     Completed Date:  1997-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-62     Citation Subset:  IM    
Department of Internal Medicine, University of Genoa, Italy.
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MeSH Terms
Aged, 80 and over
Histocompatibility Antigens Class I / blood*,  cerebrospinal fluid*
Histocompatibility Antigens Class II / blood*,  cerebrospinal fluid*
Middle Aged
Multiple Sclerosis / blood*,  cerebrospinal fluid*,  immunology
Nervous System Diseases / blood,  cerebrospinal fluid,  immunology
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II

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