| Soluble HLA-DR levels in the maternal circulation of normal and pathologic pregnancy. | |
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MedLine Citation:
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PMID: 12592258 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine that circulating HLA-DR molecules are important candidates for the monitoring of maternal immunostimulation and immunosuppression. STUDY DESIGN: Concentrations of soluble HLA-DR molecules were estimated in EDTA plasma samples of 61 nonpregnant women, 123 healthy pregnant women in the second trimester, 66 healthy women who were delivered at term, and 136 women who were delivered because of complications such as uncontrollable preterm intrauterine activation, abruptio placentae, intrauterine growth retardation, preeclampsia, and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. RESULTS: In comparison to nonpregnant women, the normal course of pregnancy was associated with strongly increasing levels of soluble HLA-DR from second trimester on until term. In comparison to women who were delivered preterm because of uncontrollable intrauterine activation, increased soluble HLA-DR concentrations were detected in case of HELLP syndrome (P <.05), although decreased levels were detected in the case of intrauterine growth retardation, preeclampsia (P <.01), and abruptio placentae (P <.01). CONCLUSION: Dysregulation of the maternal immune response to pregnancy may play an important role in the cause of complicated pregnancies. |
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Authors:
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Andrea Steinborn; Vera Rebmann; Alexander Scharf; Christof Sohn; Hans Grosse-Wilde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 188 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-19 Completed Date: 2003-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 473-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Frankfurt/Main, Germany. Steinborn@em.uni-frankfurt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abruptio Placentae
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blood Female Fetal Growth Retardation / blood HELLP Syndrome / blood HLA-DR Antigens / blood* Humans Pre-Eclampsia / blood Pregnancy / blood* Pregnancy Complications / blood* Reference Values Solubility |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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