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Soluble Glycoprotein 130 Predicts Fatal Outcomes In Chronic Heart Failure: Analysis From The Controlled Rosuvastatin Multinational Trial In Heart Failure (CORONA).
MedLine Citation:
PMID:  23230311     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: -Gp130 is the common signal-transducing receptor subunit of the IL-6 family, which may be involved in the progression of HF. We hypothesized that soluble gp130 (sgp130) would provide prognostic information beyond that of IL-6 in a heart failure (HF) population from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). METHODS AND RESULTS: -The associations of sgp130 and IL-6 with morbidity, mortality and mode of death were assessed by immunoassays in a subset of 1452 patients enrolled in the CORONA trial, which included patients with HF, aged ≥60 years, in NYHA class II-IV, who had ischemic heart disease and a reduced left ventricular ejection fraction. In multivariable analyses, including CRP, IL-6, troponin T (TnT) and NT-proBNP, elevated sgp130 (fifth quintile versus all lower quintiles) was associated with all-cause mortality (HR 1.47 [1.11-1.93], p=0.006), cardiovascular (CV) mortality (HR 1.38 [1.01-1.87], p=0.042) and death from worsening HF (WHF; HR 1.85 [1.09-3.14], p=0.002), but not with the primary endpoint (composite of death from CV causes, non-fatal myocardial infarction and non-fatal stroke; HR 1.12 [0.84-1.50], p=0.44). Plasma IL-6 was not associated with outcomes in multivariable analyses. CONCLUSIONS: -Marked elevations in sgp130 are associated with total and CV mortality, as well as deaths from WHF, in elderly patients with HF of ischemic etiology. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00206310.
Authors:
Erik Tandberg Askevold; Ståle Nymo; Thor Ueland; Jørgen Gravning; Ragnhild Wergeland; John Kjekshus; Arne Yndestad; John G F Cleland; John J V McMurray; Pål Aukrust; Lars Gullestad
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-10
Journal Detail:
Title:  Circulation. Heart failure     Volume:  -     ISSN:  1941-3297     ISO Abbreviation:  Circ Heart Fail     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101479941     Medline TA:  Circ Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Oslo University Hospital Rikshospitalet, Oslo, Norway;
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