| Soluble Fas: a useful marker of inflammation and cardiovascular diseases in uremic patients. | |
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MedLine Citation:
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PMID: 20101431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammation has been associated with atherosclerotic cardiovascular disease (CVD) and anemia in patients with end-stage renal disease (ESRD) which may lead to left ventricular impairment via myocardial hypertrophy and/or ischemia. We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation and CVD. METHODS: The study included 30 patients on hemodialysis, 30 patients with chronic kidney disease (CKD), and 30 normal control subjects. We measured serum levels of sFas, C-reactive protein (CRP), and albumin. We also investigated the association of serum sFas levels with the presence of CVD by echocardiographic assessment before and after 1 year. RESULTS: Levels of sFas were elevated in CKD and ESRD patients compared to controls. sFas levels correlated positively with serum creatinine and negatively with serum albumin. In the dialysis patients, we observed that sFas levels were higher among those with CVD. Compared with baseline, after 1 year of follow-up there was a significant decrease in left ventricular (LV) ejection fraction, increases in LV end-diastolic dimension and LV end-systolic dimension, and myocardial ischemic changes. CONCLUSIONS: These results suggest that sFas may be a marker of inflammation in CKD and ESRD patients. |
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Authors:
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Amgad E El-Agroudy; Ayman El-Baz |
Publication Detail:
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Type: Journal Article Date: 2010-01-26 |
Journal Detail:
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Title: Clinical and experimental nephrology Volume: 14 ISSN: 1437-7799 ISO Abbreviation: Clin. Exp. Nephrol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709923 Medline TA: Clin Exp Nephrol Country: Japan |
Other Details:
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Languages: eng Pagination: 152-7 Citation Subset: IM |
Affiliation:
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Urology and Nephrology Centre, University of Mansoura, Mansoura, Egypt. amgadelagroudy@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD95 / blood* Arteriosclerosis / blood* Biological Markers / blood* C-Reactive Protein / metabolism Female Humans Inflammation / blood* Kidney Failure, Chronic / blood, complications* Male Middle Aged Serum Albumin / metabolism Solubility Uremia / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/Biological Markers; 0/FAS protein, human; 0/Serum Albumin; 9007-41-4/C-Reactive Protein |
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