| Soluble Fas antigen and soluble Fas ligand in early neonatal life. | |
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MedLine Citation:
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PMID: 14652155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: After birth, apoptosis rates might slow down, compared to those in utero. Thus, factors, attenuating the apoptotic process, like the soluble forms of Fas/FasL system, may increase. AIM-STUDY DESIGN: Soluble Fas (sFas) and soluble Fas ligand (sFasL) concentrations were measured in maternal serum (MS), umbilical cord (UC) and neonatal serum in the first (1N) and fifth (5N) days after birth in order to evaluate the alterations of these molecules during the early neonatal period. SUBJECTS AND METHODS: Soluble molecules were estimated in 35 healthy, appropriate for gestational age, full-term neonates, their mothers and in 25 healthy, nonpregnant women, age-matched to the mothers (controls), using enzyme immunoassays. RESULTS: sFas concentrations in MS (p < 0.01), UC (p < 0.0001), 1N (p < 0.0003) and 5N (p < 0.02) were lower than those in controls. Neonatal sFas concentrations showed a significant increase from UC to 5N (p < 0.001). In contrast, sFasL concentrations were significantly elevated in all neonatal samples (UC, 1N and 5N) compared to those in MS and controls (p < 0.0001), showing also a significant elevation from UC to 5N (p < 0.0001). CONCLUSION: Our results demonstrate increasing serum concentrations of the soluble molecules sFas and sFasL during the first days after birth, indicating possibly a gradual decrease of apoptosis in early neonatal life. |
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Authors:
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Angeliki Sarandakou; Efthimia Protonotariou; Dimitrios Rizos; Lygeri Soubassi; Ariadni Malamitsi-Puchner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Early human development Volume: 75 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Hormone Laboratory, Ivis 101, Paleon Phaleron, 17561 Athens, Greece. dsaran@tee.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD95 / blood* Fas Ligand Protein Female Fetal Blood / chemistry Gestational Age Humans Infant, Newborn / blood* Male Maternal Age Membrane Glycoproteins / blood* Pregnancy / blood* Pregnancy, High-Risk |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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