| Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. | |
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MedLine Citation:
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PMID: 19851079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: E-selectin is a specific endothelial cell product involved in leukocyte recruitment on the endothelium, which is an important early step in the reparative process following vascular damage. In end-stage renal disease (ESRD), the relationship of E-selectin with left ventricular function has been so far neglected. METHODS: We studied 237 patients on chronic dialysis (200 on hemodialysis, 37 on continuous ambulatory peritoneal dialysis) for at least 6 months, without clinical evidence of heart failure. On a mid-week non-dialysis day, fasting blood sampling and echocardiography were performed. RESULTS: Left ventricular mass index (LVMI, corrected for height) was inversely related to E-selectin levels, increasing from 56.8 +/- 18.9 (>75th percentile E-selectin tertile) to 66.7 +/- 20.1 g/m(2.7) (<50th percentile E-selectin tertile) (p = 0.002). However, in multiple regression models, including traditional (age, sex, smoking, diabetes, systolic blood pressure, hemoglobin, albumin, previous cardiovascular events) and emerging (asymmetric dimethylarginine, interleukin-6) risk factors associated with ESRD, soluble E-selectin has proved to be a significant inverse and independent predictor of mean wall thickness, but not of LVMI. CONCLUSION: This study demonstrates that soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in ESRD patients. |
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Authors:
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Benedetta Stancanelli; Lorenzo S Malatino; Alessandro Cataliotti; Ignazio Bellanuova; Francesca Mallamaci; Giovanni Tripepi; Frank A Benedetto; Daniela Leonardis; Pasquale Fatuzzo; Francesco Rapisarda; Carmine Zoccali |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-23 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 114 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c74-80 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Division of Internal Medicine, Hypertension and Cardio-Renal Diseases Centre, Department of Internal Medicine and Systemic Diseases, University of Catania, c/o Ospedale Civile, Ragusa, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Sectional Studies E-Selectin / blood*, physiology Female Humans Kidney Failure, Chronic / blood, epidemiology, physiopathology* Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory Renal Dialysis Risk Factors Ventricular Function, Left / physiology* Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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