Document Detail


Soluble CD90 as a potential marker of pulmonary involvement in systemic sclerosis.
MedLine Citation:
PMID:  22807289     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Vascular injury and endothelial cell (EC) activation are pathogenic hallmarks of systemic sclerosis (SSc). Human CD90 is highly expressed on activated ECs and can be shed from the cell surface. This study was conducted to examine whether soluble CD90 (sCD90) is elevated in the sera of patients with SSc and linked to pulmonary involvement and in particular pulmonary arterial hypertension (PAH). METHODS: sCD90 serum concentrations were assessed in 76 patients with SSc and related to clinical data, lung function, six-minute walk distance, echocardiography, bronchoalveolar lavage fluid and laboratory parameters. Thirty-one healthy volunteers and 29 patients with idiopathic retroperitoneal fibrosis (IRF) served as controls. RESULTS: sCD90 serum concentrations were elevated in patients with SSc compared to healthy volunteers (p=0.001) and patients with IRF (p=0.01). SSc patients with pulmonary fibrosis (p=0.006) and in particular patients with PAH (p<0.001) had increased sCD90 serum concentrations compared to patients without the respective pulmonary manifestation of SSc. sCD90 levels correlated with diffusing capacity for carbon monoxide (n=65; r=-0.348; p=0.005) and systolic pulmonary arterial pressure (n=53; r=0.469; p<0.001). Receiver operating characteristics testing determined an optimal cut-off value of ≥626 ng/ml with a sensitivity of 68% and a specificity of 83% for PAH (area under the curve 0.773; 95% CI: 0.648-0.898; p<0.001). CONCLUSION: sCD90 concentrations were increased in SSc sera, particularly in patients with vascular involvement of the lung. These data suggests that sCD90 should be further evaluated as marker for diagnosis of PAH in SSc.
Authors:
Florian Kollert; Sophie Christoph; Corina Probst; Stephan Budweiser; Bettina Bannert; Moritz Binder; Bettina Sehnert; Reinhard E Voll; Klaus Warnatz; Gernot Zissel; Ulrich A Walker; Antje Prasse; Anja Saalbach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-17
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
Affiliation:
Department of Rheumatology and Clinical Immunology, University Medical Center, Freiburg, Germany. florian.kollert@uniklinik-freiburg.de.
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