Document Detail

Soluble CD40L (CD154) is increased in patients with shock.
MedLine Citation:
PMID:  20490890     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent data suggest that soluble CD40L (sCD40L) plays an important role in murine sepsis. The aim of the present study was to determine plasma levels of CD40L in critically ill patients with systemic inflammatory response syndrome (SIRS) and shock, with and without sepsis.
DESIGN: A prospective observational one-centre cohort study in a mixed-bed ICU of an university hospital. Fifty-three consecutive patients fulfilling the criteria for SIRS with shock as well as seven age-matched controls were included. ELISA was used to determine sCD40L in the plasma.
RESULTS: The level of sCD40L in plasma from healthy controls was 0.18 ± 0.03 ng/ml. It was found that sCD40L levels were significantly higher in patients with non-septic shock (0.72 ± 0.18 ng/ml) and septic shock (0.50 ± 0.1 ng/ml). However, the levels of sCD40L were not different between these two groups of patients, or in those with low and high APACHE scores.
CONCLUSION: Our data show that sCD40L is increased in patients with shock from septic and non-septic etiologies. However, further studies are needed to delineate the functional significance of sCD40L in the clinical outcome in shock patients.
M Chew; M Rahman; L Ihrman; A Erson; S Zhang; H Thorlacius
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-20
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  59     ISSN:  1420-908X     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  979-82     Citation Subset:  IM    
Department of Intensive Care Medicine, Malmö University Hospital, Lund University, Malmö, Sweden.
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MeSH Terms
CD40 Ligand / blood*
Intensive Care Units
Middle Aged
Prospective Studies
Shock, Septic / blood*,  immunology
Systemic Inflammatory Response Syndrome / blood*,  immunology
Reg. No./Substance:
147205-72-9/CD40 Ligand

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