Document Detail


Soluble CD30 in normal pregnancy, pre-eclampsia and recurrent pregnancy loss.
MedLine Citation:
PMID:  23268289     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Normal pregnancy is thought to be dependent on Th2 deviation, while Recurrent Pregnancy Loss (RPL) and Pre-eclampsia (PE) appear to be biased toward the Th1 immune response. It is believed that the soluble form of CD30 (sCD30) is an index of Th2 immune response or modulator of Th1/Th2 responses. Objective: The aim of this study was determination of the sCD30 level in RPL and PE patients. Methods: The sCD30 level was measured in sera of a group of normal non-pregnant women (N=43) and compared with normal pregnancy at the first (N=42) and third (N=42) trimester. Furthermore, the level of sCD30 in the normal first and third trimester pregnancies were compared with that of RPL (N=38) and severe pre-eclamptic (N=41) patients, respectively. sCD30 levels were measured by ELISA method and student t-test was used for statistical analysis. Results: The mean level of sCD30 at the first trimester in normal pregnancy was significantly elevated as compared with normal non-pregnant women (21.4 vs. 15.2 ng/ml, p<0.0001). A significant difference between sCD30 concentration at the first and third trimester of normal pregnancies was also observed (21.4 vs. 14.3 ng/ml, p<0.0001). Interestingly, the sCD30 concentration did not show any significant changes at the first trimester of normal pregnancy as compared with RPL (21.4 vs. 20.9 ng/ml) and third trimester of normal pregnancy as compared with PE (14.3 vs. 13.1 ng/ml). Conclusion: The data of this study indicated that the concentration of sCD30 in serum during pregnancy period is not associated with RPL or PE and serum sCD30 is not a good correlate of Th2 immune responses in pregnancy.
Authors:
Behrouz Gharesi-Fard; Leila Jafarzadeh; Jaleh Zolghadri; Hossein Haghbin
Related Documents :
15470199 - Perinatal salt restriction: a new pathway to programming insulin resistance and dyslipi...
4449059 - Changes in colostrum composition and in the permeability of the mammary epithelium at a...
25349869 - The effect of fathers' training regarding attachment skills on maternal-fetal attachmen...
6403329 - Changes in somatostatin-like activity in discrete areas of the rat hypothalamus during ...
16273349 - Increased expression and activity of heme oxygenase-2 in pregnant rat aorta is not invo...
12878049 - Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry i...
6419969 - Obstruction of the fetal urinary tract: a role for surgical intervention in utero?
10025259 - The loss of peyton.
15084019 - Effects of mating behaviour and the ovarian follicular state of female alpacas on conce...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of immunology : IJI     Volume:  9     ISSN:  1735-1383     ISO Abbreviation:  Iran J Immunol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282932     Medline TA:  Iran J Immunol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  234-40     Citation Subset:  IM    
Affiliation:
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, e-mail: gharesifb@sums.ac.ir.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population...
Next Document:  Anti-Cardiolipin and Anti-Neutrophil Cytoplasmic Antibodies in Iranian Patients with Behcet's Diseas...