| Soluble CD30 and ELISA-detected human leukocyte antigen antibodies for the prediction of acute rejection in pediatric renal transplant recipients. | |
| | |
MedLine Citation:
|
PMID: 23279372 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Biomarker-based post-transplant immune monitoring for the prediction of impending graft rejection requires validation in specific patient populations. Serum of 28 pediatric renal transplant recipients within the framework of a well-controlled prospective randomized trial was analyzed pre- and post-transplant for soluble CD30 (sCD30), a biomarker reflecting mainly T-cell reactivity, and anti-human leukocyte antigen (anti-HLA) antibody reactivity, a biomarker for B-cell activation. A sCD30 concentration ≥40.3 U/ml on day 14 was able to discriminate between patients with or without biopsy-proven acute rejection (BPAR) with a sensitivity of 100% and a specificity of 76%. Six of seven patients (86%) with BPAR showed a sCD30 above this cut-off, whereas only 3/21 patients (14%) without BPAR had a sCD30 above this cut-off (P = 0.004). For pre- and post-transplant anti-HLA class II reactivities by enzyme-linked immunosorbent assay, a cut-off value of 140 optical density was able to discriminate rejecters from nonrejecters with a sensitivity of 86% or 71% and a specificity of 81% or 90%, respectively. Withdrawal of steroids was associated with a approximately twofold higher serum sCD30 compared to controls, but did not affect anti-HLA reactivities. An increased post-transplant sCD30 serum concentration and positive pre- and post-transplant anti-HLA class II reactivities are informative biomarkers for impending BPAR in pediatric renal transplant recipients. (TWIST, Clinical Trial No: FG-506-02-43). |
| | |
Authors:
|
Heiko Billing; Anja Sander; Caner Süsal; Jörg Ovens; Reinhard Feneberg; Britta Höcker; Karel Vondrak; Ryszard Grenda; Stybjorn Friman; David V Milford; Mihai Lucan; Gerhard Opelz; Burkhard Tönshoff |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-31 |
Journal Detail:
|
Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: - ISSN: 1432-2277 ISO Abbreviation: Transpl. Int. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2013-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors Transplant International © 2012 European Society for Organ Transplantation. Published by Blackwell Publishing Ltd. |
Affiliation:
|
Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Randomized Controlled Trial on the Efficacy of Bilateral Superficial Cervical Plexus Block in Thyroi...
Next Document: Comparative study of sitagliptin with pioglitazone in Japanese type 2 diabetic patients: the COMPASS...