Document Detail

Solubilization of saponins of Bupleuri radix with ginseng saponins: cooperative effect of dammarane saponins.
MedLine Citation:
PMID:  17265304     Owner:  NLM     Status:  PubMed-not-MEDLINE    
It has been found that the water solubilities of saikosaponins, the active principles of Bupleuri radix, are greatly increased in the presence of ginsenoside-Ro, the glucuronide bisdesmoside of oleanolic acid of Ginseng. No solubilizing effect was observed with the neutral dammarane Saponins of Ginseng. However, the solubilizing effect of ginsenoside-Ro was significantly potentiated in the presence of the dammarane saponins of 20 ( S)-protopanaxadiol. The relationship between the solubilizing effect and the structure of ginsenoside-Ro was also investigated, elucidating the important role of the glucuronide moiety.
K Watanabe; H Fujino; T Morita; R Kasai; O Tanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  54     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  2007-01-31     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  405-9     Citation Subset:  -    
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Kasumi, Minami-ku, Hiroshima Japan.
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