Document Detail


Solubilization of phosphatidylcholine vesicles by hydrophobically modified poly(acrylamide)-co-(acrylic acid): effects of acrylic acid fraction and polymer concentration.
MedLine Citation:
PMID:  17685646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of hydrophobically modified copolymers of acrylamide and acrylic acid, designated as PAM-C12-AA (X%) (X% indicates the percentage of acrylic acid unit and X = 5, 10, 20), with dimyristoylphosphatidylcholine (DMPC) vesicles has been studied. Complementary techniques including isothermal titration microcalorimetry (ITC), differential scanning calorimetry (DSC), turbidity measurement, calcein leakage measurement, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were used to get comprehensive information. The results show that PAM-C12-AA leads to solubilization of DMPC vesicles. There is a critical concentration (C(s)) for PAM-C12-AA to induce obvious vesicle disruption. This concentration is very close to the critical aggregation concentration (CAC) for the polymer self-aggregation. The Cs values are found to be similar for the three polymers. However, the disruption of DMPC vesicles induced by the polymers increases to a greater degree at higher AA fraction, owing to the increasing strength of interaction between the polymer and the lipid bilayer.
Authors:
Yanru Fan; Yuchun Han; Yilin Wang
Related Documents :
19093646 - Enamel deproteinization and its effect on acid etching: an in vitro study.
2095316 - In vitro demineralization of enamel by orange juice, apple juice, pepsi cola and diet p...
2072316 - Determination of the accuracy of three die systems.
17309286 - Particulation of hyperbranched aromatic biopolyesters self-organized by solvent transfo...
5124536 - Lipogenesis from glucose-2- 14 c and acetate-1- 14 c in aorta.
24825096 - Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro):...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-09
Journal Detail:
Title:  The journal of physical chemistry. B     Volume:  111     ISSN:  1520-6106     ISO Abbreviation:  J Phys Chem B     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157530     Medline TA:  J Phys Chem B     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10123-9     Citation Subset:  IM    
Affiliation:
Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acrylamides / chemistry*
Acrylates / chemistry
Calorimetry, Differential Scanning
Dimyristoylphosphatidylcholine / chemistry*
Fluoresceins / chemistry
Hydrophobicity
Lipid Bilayers / chemistry*
Microscopy, Electron, Transmission
Permeability
Polymers / chemistry
Scattering, Radiation
Solubility
Unilamellar Liposomes / chemistry*
Chemical
Reg. No./Substance:
0/Acrylamides; 0/Acrylates; 0/Fluoresceins; 0/Lipid Bilayers; 0/Polymers; 0/Unilamellar Liposomes; 0/poly(acrylamide-co-acrylic acid); 13699-48-4/Dimyristoylphosphatidylcholine; 1461-15-0/fluorexon; 79-10-7/acrylic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Water-Nafion equilibria. absence of Schroeder's paradox.
Next Document:  Thermodynamic characterization of polyanetholesulfonic acid and its alkaline salts.