Document Detail

Solubilization of phosphatidylcholine vesicles by hydrophobically modified poly(acrylamide)-co-(acrylic acid): effects of acrylic acid fraction and polymer concentration.
MedLine Citation:
PMID:  17685646     Owner:  NLM     Status:  MEDLINE    
The interaction of hydrophobically modified copolymers of acrylamide and acrylic acid, designated as PAM-C12-AA (X%) (X% indicates the percentage of acrylic acid unit and X = 5, 10, 20), with dimyristoylphosphatidylcholine (DMPC) vesicles has been studied. Complementary techniques including isothermal titration microcalorimetry (ITC), differential scanning calorimetry (DSC), turbidity measurement, calcein leakage measurement, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were used to get comprehensive information. The results show that PAM-C12-AA leads to solubilization of DMPC vesicles. There is a critical concentration (C(s)) for PAM-C12-AA to induce obvious vesicle disruption. This concentration is very close to the critical aggregation concentration (CAC) for the polymer self-aggregation. The Cs values are found to be similar for the three polymers. However, the disruption of DMPC vesicles induced by the polymers increases to a greater degree at higher AA fraction, owing to the increasing strength of interaction between the polymer and the lipid bilayer.
Yanru Fan; Yuchun Han; Yilin Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-09
Journal Detail:
Title:  The journal of physical chemistry. B     Volume:  111     ISSN:  1520-6106     ISO Abbreviation:  J Phys Chem B     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-23     Completed Date:  2007-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157530     Medline TA:  J Phys Chem B     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10123-9     Citation Subset:  IM    
Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, People's Republic of China.
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MeSH Terms
Acrylamides / chemistry*
Acrylates / chemistry
Calorimetry, Differential Scanning
Dimyristoylphosphatidylcholine / chemistry*
Fluoresceins / chemistry
Lipid Bilayers / chemistry*
Microscopy, Electron, Transmission
Polymers / chemistry
Scattering, Radiation
Unilamellar Liposomes / chemistry*
Reg. No./Substance:
0/Acrylamides; 0/Acrylates; 0/Fluoresceins; 0/Lipid Bilayers; 0/Polymers; 0/Unilamellar Liposomes; 0/poly(acrylamide-co-acrylic acid); 13699-48-4/Dimyristoylphosphatidylcholine; 1461-15-0/fluorexon; 79-10-7/acrylic acid

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