Document Detail

Solubility study of albumin solders for laser tissue-welding.
MedLine Citation:
PMID:  9888321     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/OBJECTIVE: Current albumin solders for tissue-welding are soluble in physiological fluids, prior to laser irradiation. These solders are therefore subjected to mechanical alterations, which can weaken the solder-tissue repair. In this study, an albumin solder (laser activated) was developed with low solubility and with the ability to retain (partially) its mechanical characteristics in saline solution. STUDY DESIGN/MATERIALS AND METHODS: Gauged protein samples of solder were immersed into 0.5 ml saline solution for fixed intervals of time. The solder samples contained four bovine serum albumin (BSA) concentrations: 56%, 66%, 70%, and 75% (by weight). A Bradford protein assay measured the BSA solubility of the solders. The 70% and 75% BSA solders were also used to weld in vitro Wistar rat intestine sections with a diode laser (lambda = 810 nm, power = 270 mW). RESULTS: The solubility of the 75% BSA solder was significantly decreased with respect to the other solders (Anova, P < 0.05). This solder also showed comparable weld strength (13 gm) to the 70% BSA solder. CONCLUSION: The 75% BSA solder strongly reduced the albumin solubility in saline solution, without affecting its tissue-welding properties.
A Lauto; D P Poppas; G A Murrell
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lasers in surgery and medicine     Volume:  23     ISSN:  0196-8092     ISO Abbreviation:  Lasers Surg Med     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007168     Medline TA:  Lasers Surg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-62     Citation Subset:  IM    
The New York Hospital-Cornell University Medical Center, New York 10021, USA.
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MeSH Terms
Analysis of Variance
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Indicators and Reagents
Intestines / surgery
Laser Therapy* / methods
Linear Models
Rats, Wistar
Serum Albumin, Bovine / analysis,  chemistry*,  radiation effects,  therapeutic use
Solubility / radiation effects
Tissue Adhesives / analysis,  chemistry*,  radiation effects,  therapeutic use
Reg. No./Substance:
0/Indicators and Reagents; 0/Serum Albumin, Bovine; 0/Tissue Adhesives

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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