Document Detail


Solubility studies of silver sulfonamides.
MedLine Citation:
PMID:  26788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The solubilities of silver sulfapyridine, silver sulfamethazine, and silver sulfamethizole as a function of pH were determined in nitric acid-potassium nitrate, acetate, and sulfonic acid buffers. All silver sulfonamides showed an increase in solubility with increasing hydrogen-ion concentration, a behavior which closely paralleled the protonation of the p-amino function of the sulfonamide. A silver-ion selective electrode was used to measure silver-ion concentration in solution and the methods of known subtraction and known addition were used to measure total silver. Both silver sulfamethizole and silver sulfamethazine were ionized completely in solution. Silver sulfapyridine was ionized completely only in the more acidic pH 2-3 range. A comparison of the physical properties of the silver salts for which mortality studies were available revealed a unique set of properties for silver sulfadiazine.
Authors:
R U Nesbitt; B J Sandmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  67     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2001-03-23    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1012-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Hydrogen-Ion Concentration
Silver
Solubility
Sulfamethazine*
Sulfamethizole*
Sulfanilamides*
Sulfapyridine*
Sulfathiazoles*
Chemical
Reg. No./Substance:
0/Sulfanilamides; 0/Sulfathiazoles; 144-82-1/Sulfamethizole; 144-83-2/Sulfapyridine; 57-68-1/Sulfamethazine; 7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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