| Solubility of sparingly-soluble ionizable drugs. | |
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MedLine Citation:
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PMID: 17644216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The experimental and computational basis of the pH-dependent measurement of solubility of sparingly-soluble ionizable drugs is reviewed. Recently described compound-sparing (but still accurate) approaches, suitable for application in preclinical development, and appropriate for the analysis of solubility of "problematic" molecules, are critically examined. A number of useful experimental methods are reviewed, including the miniaturized shake-flask microtitre plate, the micro solubility self-calibrating direct UV, potentiometric, and the micro dissolution methods. Several molecules were selected as case studies to illustrate important concepts, with re-analysis of literature data using recently established computational tools. |
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Authors:
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Alex Avdeef |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-05-29 |
Journal Detail:
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Title: Advanced drug delivery reviews Volume: 59 ISSN: 0169-409X ISO Abbreviation: Adv. Drug Deliv. Rev. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2008-01-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8710523 Medline TA: Adv Drug Deliv Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 568-90 Citation Subset: IM |
Affiliation:
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pION INC, 5 Constitution Way, Woburn, MA 01801 USA. aavdeef@pion-inc.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Chemistry, Physical Excipients / chemistry Hydrogen-Ion Concentration Ions / chemistry Pharmaceutical Preparations / chemistry Pharmacokinetics* Physicochemical Phenomena Potentiometry Solubility |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Ions; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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