Document Detail

Solubility profiles of some isoxazolyl-naphthoquinone derivatives.
MedLine Citation:
PMID:  10528095     Owner:  NLM     Status:  MEDLINE    
Water, ethanol and n-hexane solubility and pH-solubility behavior of a homologous series of isoxazolyl-naphthoquinone derivatives, which exhibit important biological activity, were studied. Their pK(a) values were determined spectrophotometrically as well as from their pH-solubility profiles. Also, the molar aqueous solubility of these compounds was estimated with the equations developed by Yalkowsky and Valvani using the data of their melting points and octanol/water partition coefficients.
G Granero; M M de Bertorello; M C Briñón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  190     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  41-7     Citation Subset:  IM    
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina.
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MeSH Terms
Chemistry, Pharmaceutical
Chemistry, Physical
Ethanol / chemistry
Hexanes / chemistry
Hydrogen-Ion Concentration
Isoxazoles / chemistry*
Naphthols / chemistry*
Octanols / chemistry
Physicochemical Phenomena
Water / chemistry
Reg. No./Substance:
0/Hexanes; 0/Isoxazoles; 0/Naphthols; 0/Octanols; 110-54-3/n-hexane; 64-17-5/Ethanol; 7732-18-5/Water

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