| Solubility parameter and oral absorption. | |
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MedLine Citation:
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PMID: 10612038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The solubility parameter (delta) for a series of structurally diverse compounds was determined using a group contribution method devised by Fedors, and then related to the degree of oral absorption. Solubility parameter values around 22.5 MPa1/2 were shown to be associated with compounds that were well absorbed, whereas, compounds with a high delta (30-40 MPa1/2) showed poor absorption. A correlation was also evident between the number of H-bonding acceptor groups in a compound and the extent of oral absorption. Surprisingly, when C Log P values were used in comparison, no obvious correlation existed. The conclusion from this work is that the solubility parameter may be a more reasonable predictor of absorption than using C Log P values. |
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Authors:
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L G Martini; P Avontuur; A George; R J Willson; P J Crowley |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Volume: 48 ISSN: 0939-6411 ISO Abbreviation: Eur J Pharm Biopharm Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-20 Completed Date: 2000-01-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9109778 Medline TA: Eur J Pharm Biopharm Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-63 Citation Subset: IM |
Affiliation:
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SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK. luigi_g_martini@sbphrd.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Chemistry, Pharmaceutical Humans Mice Mouth Mucosa / metabolism* Pharmacokinetics* Ranidae Rats Solubility Structure-Activity Relationship Swine |
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