| Solubility of nonelectrolytes in polar solvents III: Alkyl p-aminobenzoates in polar and mixed solvents. | |
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MedLine Citation:
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PMID: 1133705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relative solubilities of n-alkyl p-aminobenzoates in water, proplyene blycol-water mixtures, proplyene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theorectical relationship are compared to those of the Scatchard-Hildebrand approach. |
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Authors:
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S H Yalkowsky; G L Amidon; G Zografi; G L Flynn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 64 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-08-26 Completed Date: 1975-08-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 48-52 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohols Aminobenzoic Acids* / analogs & derivatives Chemical Phenomena Chemistry Electrolytes Models, Chemical Propylene Glycols Solubility Surface Tension Thermodynamics Water |
| Chemical | |
Reg. No./Substance:
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0/Alcohols; 0/Aminobenzoic Acids; 0/Electrolytes; 0/Propylene Glycols; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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