Document Detail

Solubility of nonelectrolytes in polar solvents III: Alkyl p-aminobenzoates in polar and mixed solvents.
MedLine Citation:
PMID:  1133705     Owner:  NLM     Status:  MEDLINE    
The relative solubilities of n-alkyl p-aminobenzoates in water, proplyene blycol-water mixtures, proplyene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theorectical relationship are compared to those of the Scatchard-Hildebrand approach.
S H Yalkowsky; G L Amidon; G Zografi; G L Flynn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  64     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-08-26     Completed Date:  1975-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-52     Citation Subset:  IM; S    
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MeSH Terms
Aminobenzoic Acids* / analogs & derivatives
Chemical Phenomena
Models, Chemical
Propylene Glycols
Surface Tension
Reg. No./Substance:
0/Alcohols; 0/Aminobenzoic Acids; 0/Electrolytes; 0/Propylene Glycols; 7732-18-5/Water

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