| Solitary mastocytoma occurring at a site of trauma. | |
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MedLine Citation:
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PMID: 19397569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe a patient with a solitary mastocytoma arising at a site of trauma. The patient was born with the umbilical cord wrapped around her right thigh and subsequently developed a solitary mastocytoma in the exact site and distribution of this injury. The pathogenesis of mast cell proliferation in solitary mastocytoma is not completely understood. Cytokines released after injury, such as stem cell factor, may stimulate the proliferation of mast cells, as well as fibroblasts and melanocytes to form a mastocytoma. Mast cells in a newborn may be more sensitive to stem cell factor in the presence of cytokines released after injury due to an increased density of c-kit receptors. We present our patient and review the literature to support a hypothesis that this condition represents a reactive, and not neoplastic, process. |
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Authors:
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Alana Jane Tuxen; David Orchard |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Australasian journal of dermatology Volume: 50 ISSN: 1440-0960 ISO Abbreviation: Australas. J. Dermatol. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-08-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0135232 Medline TA: Australas J Dermatol Country: Australia |
Other Details:
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Languages: eng Pagination: 133-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology The Royal Children's Hospital, Melbourne, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Betamethasone / analogs & derivatives, therapeutic use Birth Injuries / physiopathology* Female Humans Infant Infant, Newborn Mastocytoma, Skin / diagnosis*, drug therapy, etiology*, metabolism Proto-Oncogene Proteins c-kit / metabolism Thigh / injuries* Treatment Outcome Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 378-44-9/Betamethasone; 5593-20-4/betamethasone-17,21-dipropionate; EC 2.7.10.1/Proto-Oncogene Proteins c-kit |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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