Document Detail

Solitary fibrous tumor of the meninges: two new cases and review of the literature.
MedLine Citation:
PMID:  10369232     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Solitary fibrous tumor (SFT), a mesenchymal neoplasm originally described in the pleura has been more recently reported to arise in a number of other sites, including the meninges. Nowadays immunohistochemistry facilitates the otherwise problematic differential diagnosis with regard to other benign and malignant spindle cell neoplasms of the central nervous system. METHODS: Two recently treated cases of meningeal SFT (one craniospinal, one spinal) are presented and discussed in the light of the present knowledge and a review of the literature. RESULTS: Total resection was followed by complete recovery and both patients are presently asymptomatic and without evidence of disease. The microscopic and immunohistochemical profiles (CD 34, vimentin positive; S-100, EMA negative) were consistent with those of previously reported cases. CONCLUSIONS: The majority of SFTs behave in a benign fashion and do not recur unless subtotally resected. Malignant variants may account for up to 37% of SFTs in other locations but have never been reported to occur in the meninges. Meningeal SFTs are to be considered a new pathological entity. Wider use of immunohistochemical screening should enable the determination of their real incidence; larger series and longer follow-up will provide conclusions about their treatment and prognosis.
A Brunori; S Cerasoli; R Donati; F Giangaspero; F Chiappetta
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Surgical neurology     Volume:  51     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-23     Completed Date:  1999-06-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  636-40     Citation Subset:  IM    
Azienda Ospedaliera San Camillo-Forlanini, Dip. di Neuroscienze G.M. Lancisi, Rome, Italy.
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MeSH Terms
Diagnosis, Differential
Fibroma / pathology*,  surgery
Hemangiopericytoma / pathology*,  surgery
Meningeal Neoplasms / pathology*,  surgery
Meningioma / pathology*,  surgery
Middle Aged

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