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Solitary Tracheobronchial Papilloma: Cytomorphology and ancillary studies with histologic correlation.
MedLine Citation:
PMID:  21383960     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Solitary tracheobronchial papilloma (STBP) is a rare benign tumor that primarily involves the tracheobronchial tree. Human papilloma virus (HPV) infection is associated with dysplasia and a high risk of carcinoma in these lesions. The cytomorphology of STBP is not well established in the literature. Our aim is to characterize the cytomorphologic features of STBP, with histologic correlation in a series of 6 patients - 4 males and 2 females - with a mean age of 67 years (range, 53-88 years). There were 5 biopsy-proven squamous papillomas and 1 glandular papilloma. On surgical biopsy, squamous papillomas exhibited cytological atypia (4 graded mild and 1 graded moderate with focal severe dysplasia), surface erosion, and inflammation. Cytology specimens available for review included a combination of 4 fine-needle aspirations (FNAs), 2 bronchoalveolar lavages and 2 (of 3) bronchial brushings. Cytologic findings associated with squamous papillomas included atypical squamous cells and rare squamous cell resembling koilocyte in 1 bronchial brushing. Sheets of squamous cells were identified in another specimen. Several cases had a prominent background of acute inflammation, and candida was present in 1 specimen. HPV in-situ hybridization was positive in 1 case and negative in 2 cases. A p16 immunocytochemical stain performed on 1 cell block was negative. In conclusion, although STBP is a rare neoplasm, these cases may be encountered in respiratory cytology samples. FNA of papillomas yields fewer lesional cells compared to exfoliative samples. These lesions may be mistaken in cytology specimens for squamous cell carcinoma, squamous-lined cavitary lesions, an infectious (fungal) process, reactive squamous metaplasia, or oral contamination.
Authors:
Tee U Lang; Walid E Khalbuss; Sara E Monaco; Liron Pantanowitz
Publication Detail:
Type:  Journal Article     Date:  2011-03-03
Journal Detail:
Title:  CytoJournal     Volume:  8     ISSN:  1742-6413     ISO Abbreviation:  Cytojournal     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-08     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101231642     Medline TA:  Cytojournal     Country:  India    
Other Details:
Languages:  eng     Pagination:  6     Citation Subset:  -    
Affiliation:
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
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