Document Detail


Solitary pulmonary nodules caused by Mycobacterium tuberculosis and Mycobacterium avium complex.
MedLine Citation:
PMID:  19956964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Few studies have compared the clinical and radiographic findings of tuberculomas to those of solitary pulmonary nodules (SPNs) caused by Mycobacterium avium complex (MAC). We retrospectively analyzed clinical and radiographic findings from 26 patients with tuberculomas and 15 patients with SPNs caused by MAC. Median SPN size was 22 mm. In 26 patients (63%), the SPN was detected during a routine health checkup or evaluation of organs other than lungs. Patients with SPNs due to MAC were slightly older (median = 59 years) compared with those with tuberculomas (median = 50 years; P = 0.044). When we compared computed tomography (CT) features between patients with tuberculomas and patients with MAC, no significant differences were found in SPN location or the presence of calcification, cavitation, central low attenuation, and the satellite lesions. Although the maximum standardized uptake values were slightly higher in patients with SPNs due to MAC (median = 8.5) compared with those with tuberculomas (median = 2.2), this difference was not significant (P = 0.053). Of the 15 patients with SPNs due to MAC, 10 were initially diagnosed with "tuberculoma" and administered antituberculosis medication. MAC pulmonary disease should be considered in the differential diagnosis of SPNs, even when encountered in geographic regions with a high prevalence of pulmonary tuberculosis.
Authors:
Cho Rom Hahm; Hye Yun Park; Kyeongman Jeon; Sang-Won Um; Gee Young Suh; Man Pyo Chung; Hojoong Kim; O Jung Kwon; Won-Jung Koh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-03
Journal Detail:
Title:  Lung     Volume:  188     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Affiliation:
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antitubercular Agents / therapeutic use
Biopsy
Diagnosis, Differential
Female
Fluorodeoxyglucose F18 / diagnostic use
Humans
Male
Middle Aged
Mycobacterium avium Complex / isolation & purification*
Mycobacterium tuberculosis / isolation & purification*
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use
Retrospective Studies
Solitary Pulmonary Nodule / diagnosis,  drug therapy,  microbiology*
Sputum / microbiology
Tomography, X-Ray Computed
Tuberculoma / diagnosis,  drug therapy,  microbiology*
Tuberculosis, Pulmonary / diagnosis,  drug therapy,  microbiology*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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