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Solitary Necrotic Nodules of the Liver: Histology and Diagnosis With CT and MRI.
MedLine Citation:
PMID:  23087753     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A solitary necrotic nodule (SNN) of the liver is an uncommon lesion, which is different from primary and metastatic liver cancers.
OBJECTIVES: To analyze the classification, CT and MR manifestation, and the pathological basis of solitary necrotic nodule of the liver (SNN) in order to evaluate CT and MRI as a diagnosing tool.
PATIENTS AND METHODS: This study included 29 patients with liver SNNs, out of which 14 had no clinical symptoms and were discovered by routine ultrasound examinations, six were found by computed tomography (CT) due to abdominal illness, four had ovarian tumors, and five had gastrointestinal cancer surgeries, previously. Histologically, these SNNs can be divided into three subtypes, i.e., type I, pure coagulation necrosis (14 cases); type II, coagulation necrosis mixed with liquefaction necrosis (five cases); and type III, multi-nodular fusion (10 cases). CT and magnetic resonance imaging (MRI) patterns were shown to be associated with SNN histology. All patients were treated surgically with good prognosis.
RESULTS: CT AND MRI APPEARANCE AND CORRELATION WITH PATHOLOGY TYPES: three subtypes of lesions were hypo-density on both pre contrast and post contrast CT, 12 lesions were found the enhanced capsule and 1 lesion of multi- nodular fusion type showed septa enhancement. The lesions were hypo-intensity on T2WI and the lesions of type II showed as mixed hyperintensity on T2WI. The capsule showed delayed enhancement in all cases, and all lesions of multi- nodular fusion type showed delayed septa enhancement on MR images. 15 cases on CT were misdiagnosed and Four cases on MRI were misdiagnosed and the accuracy of CT and MRI were 48.3% and 86.2% respectively.
CONCLUSIONS: In conclusion, CT and MRI are useful tools for SNN diagnosis.
Authors:
Li Xia Wang; Kan Liu; Guang Wu Lin; Ren You Zhai
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Publication Detail:
Type:  Journal Article     Date:  2012-08-20
Journal Detail:
Title:  Hepatitis monthly     Volume:  12     ISSN:  1735-3408     ISO Abbreviation:  Hepat Mon     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2012-10-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101277874     Medline TA:  Hepat Mon     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  e6212     Citation Subset:  -    
Affiliation:
Department of Radiology, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, China.
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