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Solitary Bone Plasmacytoma Progressing into Retroperitoneal Plasma Cell Myeloma with No Related End Organ or Tissue Impairment: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  25330522     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Solitary bone plasmacytomas and plasma cell myeloma are clonal proliferations of plasma cells. Many patients with solitary bone plasmacytomas develop plasma cell myeloma on follow-up. We present a case of a 70-year-old man who presented with fracture and a lytic lesion in the subtrochanteric region of the left femur and was assigned a diagnosis of solitary bone plasmacytoma. He received local curative radiotherapy. However, 4 months later his serum M protein and β2-microglobulin levels increased to 2.31 g/dL and 5.965 mg/L, respectively. He complained of abdominal fullness and constipation. Ultrasound and non-contrast CT imaging revealed multiple retroperitoneal masses. Colonoscopic examination was normal. Biopsy of the a retroperitoneal mass confirmed it to be a plasmacytoma. Repeat hemogram, blood urea, serum creatinine, skeletal survey, and bone marrow examination revealed no abnormalities. This is an unusual presentation of plasma cell myeloma, which manifested as multiple huge extramedullary retroperitoneal masses and arose from a solitary bone plasmacytoma, without related end organ or tissue impairment and bone marrow plasmacytosis. The patient succumbed to his disease 8 months after the appearance of the retroperitoneal masses. This case highlights the importance of close monitoring of patients diagnosed with solitary bone plasmacytoma with increased serum M protein and serum β2-microglobulin levels, so that early therapy can be instituted to prevent conversion to plasma cell myeloma.
Abstract available from the publisher.
Authors:
Gargi Tikku; Monica Jain; Asit Mridha; Rajesh Grover
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Turkish journal of haematology : official journal of Turkish Society of Haematology     Volume:  31     ISSN:  1300-7777     ISO Abbreviation:  Turk J Haematol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9606065     Medline TA:  Turk J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  286-289     Citation Subset:  -    
Vernacular Title:
Hedef Organ ya da Doku Disfonksiyonuna Yol Açmadan Retroperitoneal Plazma Hücreli Miyeloma Progrese Olan Soliter Kemik Plazmasitomu: Bir Olgu Sunumu ve Literatür Derlemesi.
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