| Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers. | |
| | |
MedLine Citation:
|
PMID: 18428992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Simultaneous improvement of solubilization kinetics of main flavolignans of Silybum marianum extract was obtained cogrinding with two crosslinked polymers: micronized crospovidone, PVP-CL(R) and sodium carboxymethylcellulose, Ac-Di-Sol(R) in the 1:3 active-to-polymer weight ratio. By this process it was assessed that the main extract components lost its crystalline structure, and the powder surface area was increased by 2.1- and 1.7-fold in the coground products with Ac-Di-Sol(R) and PVP-CL(R), respectively. This activated status of the dry extract remained stable over a period of 2 years. Solubilization kinetics resulted ameliorated both in terms of entire dry extract and in terms of single components. When the 1/3 coground systems with PVP-CL(R) and Ac-Di-Sol(R) were dissolved in saturated conditions they gave a concentration improvement compared to the native product of 8 and 31 times of silybin A, 7 and 27 times of silybin B, whereas in the case of silychristin a double concentration was obtained only using Ac-Di-Sol(R). The in vivo studies on rats confirmed that this solubilization improvement corresponded to an effective oral bioavailability enhancement. The highest bioavailability improvement was obtained with Ac-Di-Sol(R), with a relative bioavailability of 88.6, 17.96, and 16.4 compared to the extract for silybin A, silybine B, and silychristine, respectively. |
| | |
Authors:
|
D Voinovich; B Perissutti; L Magarotto; D Ceschia; P Guiotto; A R Bilia |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pharmaceutical sciences Volume: 98 ISSN: 1520-6017 ISO Abbreviation: J Pharm Sci Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2008-12-02 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 215-28 Citation Subset: IM |
Copyright Information:
|
(c) 2008 Wiley-Liss, Inc. and the American Pharmacists Association |
Affiliation:
|
Department of Pharmaceutical Sciences, University of Trieste, P. le Europa 1, I-34127 Trieste, Italy. vojnovic@units.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biomechanics / physiology Cross-Linking Reagents / chemistry*, pharmacokinetics* Male Milk Thistle / chemistry* Plant Extracts / chemistry, pharmacokinetics Polymers / chemistry*, pharmacokinetics* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Cross-Linking Reagents; 0/Plant Extracts; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two peculiar conditions following a coma: a clinical case of heterotopic ossification concomitant wi...
Next Document: Body symmetry and asymmetry in early Greek anatomical reasoning.