Document Detail


Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.
MedLine Citation:
PMID:  23073186     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.
Authors:
Mark D Eddleston; Mihails Arhangelskis; Tomislav Friščić; William Jones
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-16
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. wj10@cam.ac.uk.
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