| Solid-state decomposition of para-substituted salicylic acids. | |
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MedLine Citation:
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PMID: 1206484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of para-substituted salicylic acids, all crystallizing monoclinically and decomposing by decarboxylation, were shown to adhere to Bawn-type kinetics, and the decomposition rate constants were shown to adhere approximately to a Hammett-type relation. The value of the reaction parameter was -8. Both para-substituted salicyclic and benzoic acids occur as dimers in the crystalline state. The mechanism whereby the latter decomposes is speculated to be intermolecular in the sense that the substituent from one dimer interacts with the carboxyl group of a neighboring dimer. In the same sense of the word, the substituted salicyclic acids decompose by an intramolecular mechanism, i.e., within the dimer unit. |
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Authors:
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P Pothisiri; J T Carstensen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 64 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-04-01 Completed Date: 1976-04-01 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1931-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Decarboxylation Drug Stability Kinetics Models, Chemical Phenols Salicylic Acids* Temperature |
| Chemical | |
Reg. No./Substance:
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0/Phenols; 0/Salicylic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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