Document Detail

Solid-state decomposition of para-substituted salicylic acids.
MedLine Citation:
PMID:  1206484     Owner:  NLM     Status:  MEDLINE    
A series of para-substituted salicylic acids, all crystallizing monoclinically and decomposing by decarboxylation, were shown to adhere to Bawn-type kinetics, and the decomposition rate constants were shown to adhere approximately to a Hammett-type relation. The value of the reaction parameter was -8. Both para-substituted salicyclic and benzoic acids occur as dimers in the crystalline state. The mechanism whereby the latter decomposes is speculated to be intermolecular in the sense that the substituent from one dimer interacts with the carboxyl group of a neighboring dimer. In the same sense of the word, the substituted salicyclic acids decompose by an intramolecular mechanism, i.e., within the dimer unit.
P Pothisiri; J T Carstensen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  64     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1976-04-01     Completed Date:  1976-04-01     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1931-5     Citation Subset:  IM    
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MeSH Terms
Chemistry, Pharmaceutical
Drug Stability
Models, Chemical
Salicylic Acids*
Reg. No./Substance:
0/Phenols; 0/Salicylic Acids

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