Document Detail

Solid pseudopapillary pancreatic tumor in pregnancy. A case report.
MedLine Citation:
PMID:  14976799     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm, occurring predominantly in young African American women. Tumor growth, which is typically slow, may be accelerated during pregnancy secondary to the influence of progesterone. CASE: We report a rare case of an 8-cm SPT in the head of the pancreas presenting as hyperemesis gravidarum during pregnancy. In contrast to previous case reports, surgical resection of the tumor at 16 weeks' gestation, although successful, did not ameliorate the patient's abdominal pain, nausea or vomiting. With intravenous nutritional support, she delivered a healthy infant near term. CONCLUSION: SPT may present as hyperemesis gravidarum. Patients with refractory hyperemesis gravidarum should be evaluated for thyroid disease, gastroesophageal reflux, cholestasis and pancreatitis. If these more common etiologies are excluded, then one may consider SPT in the differential diagnosis, particularly in African American patients. SPT may grow during pregnancy due to progesterone responsiveness. Surgical resection during pregnancy is possible without harmful fetal effects but may not correct gastrointestinal dysfunction during pregnancy.
Chanan Levy; Leonardo Pereira; Thomas Dardarian; Elyce Cardonick
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  49     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-02-23     Completed Date:  2004-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University, Pennsylvania Hospital, Philadelphia, USA.
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MeSH Terms
Carcinoma, Papillary / complications,  diagnosis*,  surgery
Diagnosis, Differential
Enterocolitis, Necrotizing / etiology
Hyperemesis Gravidarum / complications,  diagnosis,  therapy
Infant, Low Birth Weight
Infant, Newborn
Magnetic Resonance Imaging
Pancreatic Neoplasms / complications,  diagnosis*,  surgery
Pancreaticoduodenectomy / methods*
Parenteral Nutrition, Home Total
Pregnancy Complications, Neoplastic*
Pregnancy Outcome
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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