| Solid-phase synthesis of potential protein tyrosine phosphatase inhibitors via the Ugi four-component condensation. | |
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MedLine Citation:
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PMID: 9873558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A library of 108 alpha,alpha-difluoromethylenephosphonic acids was prepared by Ugi four-component condensation using Rink-NH2 resin, 4-[(diethoxyphosphinyl) difluoromethyl]benzoic acid, and a set of 18 aldehydes and 6 isonitriles. Following resin cleavage, the diethylphosphonate esters were hydrolyzed with trimethylsilyl bromide to yield the free acids which were assayed for inhibition of PTP alpha, PTP beta and PTP epsilon. |
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Authors:
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Z Li; S L Yeo; C J Pallen; A Ganesan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 8 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1999-02-02 Completed Date: 1999-02-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2443-6 Citation Subset: IM |
Affiliation:
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Institute of Molecular and Cell Biology, National University of Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes Chromatography, High Pressure Liquid Enzyme Inhibitors / chemical synthesis* Iodobenzoates Magnetic Resonance Spectroscopy Models, Chemical Nitriles Phosphonic Acids* / chemistry Protein Conformation Protein Tyrosine Phosphatases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Enzyme Inhibitors; 0/Iodobenzoates; 0/Nitriles; 0/Phosphonic Acids; EC 3.1.3.48/Protein Tyrosine Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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