| Solid-phase synthesis of oligonucleotide conjugates useful for delivery and targeting of potential nucleic acid therapeutics. | |
| | |
MedLine Citation:
|
PMID: 19175328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Olignucleotide-based drugs show promise as a novel form of chemotherapy. Among the hurdles that have to be overcome on the way of applicable nucleic acid therapeutics, inefficient cellular uptake and subsequent release from endosomes to cytoplasm appear to be the most severe ones. Covalent conjugation of oligonucleotides to molecules that expectedly facilitate the internalization, targets the conjugate to a specific cell-type or improves the parmacokinetics offers a possible way to combat against these shortcomings. Since workable chemistry is a prerequisite for biological studies, development of efficient and reproducible methods for preparation of various types of oligonucleotide conjugates has become a subject of considerable importance. The present review summarizes the advances made in the solid-supported synthesis of oligonucleotide conjugates aimed at facilitating the delivery and targeting of nucleic acid drugs. |
| | |
Authors:
|
Harri Lönnberg |
Related Documents
:
|
11297928 - Recent advances in fret: distance determination in protein-dna complexes. 15610028 - Ionic mobilities of duplex and frayed wire dna in discontinuous buffer electrophoresis:... 3047068 - Isolation of listeria: a review of procedures and future prospects. 17847128 - Sensitive fluorescence detection of polyphosphate in polyacrylamide gels using 4',6-dia... 21700058 - Short communication: influence of the muscle hypertrophy mutation of the myostatin gene... 6779008 - 8-hydroxyanthracyclinones from epsilon-rhodomycinone. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Bioconjugate chemistry Volume: 20 ISSN: 1520-4812 ISO Abbreviation: Bioconjug. Chem. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-18 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 1065-94 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Turku, FIN-20014 Turku, Finland. harlon@utu.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Drug Carriers / chemical synthesis*, chemistry Glycoconjugates / chemistry Humans Nucleic Acids / chemistry*, metabolism, therapeutic use* Oligonucleotides / chemistry*, metabolism, therapeutic use* Peptides / chemistry Polyamines / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Drug Carriers; 0/Glycoconjugates; 0/Nucleic Acids; 0/Oligonucleotides; 0/Peptides; 0/Polyamines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of Molecular Fingerprint Methods on the Basis of Biological Profile Data.
Next Document: Development and Characterization of an Aircraft Aerosol Time-of-Flight Mass Spectrometer.