Document Detail


Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood.
MedLine Citation:
PMID:  8878255     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A HPLC method for quantification of kebuzone and its metabolites in whole blood was developed. The compounds and the internal standard were isolated from blood by solid-phase extraction on a C-18 cartridge. A blood sample was to be hemolyzed before extraction. HPLC was performed on a C-18 column with the mobile phase composed of methanol/water acidified to pH 2.7 and UV absorbance detection at 247 nm. This method has been successfully applied to a pharmacokinetic study of kebuzone and its metabolites in rabbits.
Authors:
J Klimes; J Sochor; J Sedlacek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  51     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-04     Completed Date:  1997-02-04     Revised Date:  2009-10-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  651-3     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Repulic.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / blood*,  pharmacokinetics
Central Nervous System Depressants / blood,  pharmacokinetics
Chromatography, High Pressure Liquid
Methaqualone / blood,  pharmacokinetics
Phenylbutazone / analogs & derivatives*,  blood,  pharmacokinetics
Rabbits
Spectrophotometry, Ultraviolet
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Central Nervous System Depressants; 50-33-9/Phenylbutazone; 72-44-6/Methaqualone; 853-34-9/kebuzone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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