| Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood. | |
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MedLine Citation:
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PMID: 8878255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A HPLC method for quantification of kebuzone and its metabolites in whole blood was developed. The compounds and the internal standard were isolated from blood by solid-phase extraction on a C-18 cartridge. A blood sample was to be hemolyzed before extraction. HPLC was performed on a C-18 column with the mobile phase composed of methanol/water acidified to pH 2.7 and UV absorbance detection at 247 nm. This method has been successfully applied to a pharmacokinetic study of kebuzone and its metabolites in rabbits. |
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Authors:
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J Klimes; J Sochor; J Sedlacek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 51 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-02-04 Completed Date: 1997-02-04 Revised Date: 2009-10-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 651-3 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Repulic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / blood*, pharmacokinetics Central Nervous System Depressants / blood, pharmacokinetics Chromatography, High Pressure Liquid Methaqualone / blood, pharmacokinetics Phenylbutazone / analogs & derivatives*, blood, pharmacokinetics Rabbits Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Central Nervous System Depressants; 50-33-9/Phenylbutazone; 72-44-6/Methaqualone; 853-34-9/kebuzone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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