| Solid lipid nanoparticles as drug delivery systems. | |
| | |
MedLine Citation:
|
PMID: 15834465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
For a decade, trials have been made to utilize solid lipid nanoparticles (SLNs) as alternative drug delivery systems to colloidal drug delivery systems such as lipid emulsions, liposomes, and polymeric nanoparticles. Various lipid matrices, surfactants, and other excipients used in formulation, preparation methods, sterilization and lyophilization of SLNs are discussed in this article. Entrapment efficiency of drug carrier and its effect on physical parameters, drug release, and release mechanisms of various compositions are reviewed and discussed. Important points in characterization and stability of SLNs are outlined. Various in vitro studies carried out by different research groups are mentioned in addition to in vivo evaluation. Exploitation potential of SLNs to administer by various routes of administration are covered. Passive and active drug targeting using SLNs are presented. |
| | |
Authors:
|
K Manjunath; J S Reddy; V Venkateswarlu |
Related Documents
:
|
12490375 - A lipophilic paclitaxel derivative incorporated in a lipid emulsion for parenteral admi... 8099955 - Microspheres of human serum albumin with barbiturates: effect of drug partition coeffic... 20061595 - Preparation, characterization and in silico modeling of biodegradable nanoparticles con... 16456875 - Novel functional hyperbranched polyether polyols as prospective drug delivery systems. 15972585 - Drug-induced disorders of teeth. 10137645 - Medicaid program; drug use review program and electronic claims management system for o... |
Publication Detail:
|
Type: In Vitro; Journal Article; Review |
Journal Detail:
|
Title: Methods and findings in experimental and clinical pharmacology Volume: 27 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-04-18 Completed Date: 2005-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: Spain |
Other Details:
|
Languages: eng Pagination: 127-44 Citation Subset: IM |
Copyright Information:
|
Copyright 2005 Prous Science. All rights reserved. |
Affiliation:
|
Novel Drug Delivery System Laboratory, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Drug Compounding Drug Delivery Systems* Drug Stability Emulsifying Agents Lipids / chemistry* Nanostructures* Nanotechnology Particle Size Solubility |
| Chemical | |
Reg. No./Substance:
|
0/Emulsifying Agents; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical evidence for drug treatments in obesity-associated hypertensive patients--a discussion pape...
Next Document: Detection of explosives on solid surfaces by thermal desorption and ambient ion/molecule reactions.